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Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency.
Stoszko M, Al-Hatmi AMS, Skriba A, Roling M, Ne E, Crespo R, Mueller YM, Najafzadeh MJ, Kang J, Ptackova R, LeMasters E, Biswas P, Bertoldi A, Kan TW, de Crignis E, Sulc M, Lebbink JHG, Rokx C, Verbon A, van Ijcken W, Katsikis PD, Palstra RJ, Havlicek V, de Hoog S, Mahmoudi T. Stoszko M, et al. Among authors: mahmoudi t. Sci Adv. 2020 Aug 12;6(33):eaba6617. doi: 10.1126/sciadv.aba6617. eCollection 2020 Aug. Sci Adv. 2020. PMID: 32851167 Free PMC article.
Non-muscle-invasive bladder cancer molecular subtypes predict differential response to intravesical Bacillus Calmette-Guérin.
de Jong FC, Laajala TD, Hoedemaeker RF, Jordan KR, van der Made ACJ, Boevé ER, van der Schoot DKE, Nieuwkamer B, Janssen EAM, Mahmoudi T, Boormans JL, Theodorescu D, Costello JC, Zuiverloon TCM. de Jong FC, et al. Among authors: mahmoudi t. Sci Transl Med. 2023 May 24;15(697):eabn4118. doi: 10.1126/scitranslmed.abn4118. Epub 2023 May 24. Sci Transl Med. 2023. PMID: 37224225 Free PMC article.
Transcription: Insights From the HIV-1 Promoter.
Ne E, Palstra RJ, Mahmoudi T. Ne E, et al. Among authors: mahmoudi t. Int Rev Cell Mol Biol. 2018;335:191-243. doi: 10.1016/bs.ircmb.2017.07.011. Epub 2017 Oct 12. Int Rev Cell Mol Biol. 2018. PMID: 29305013 Review.
Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal.
Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC. Marian CA, et al. Among authors: mahmoudi t. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14. doi: 10.1016/j.chembiol.2018.08.004. Epub 2018 Sep 6. Cell Chem Biol. 2018. PMID: 30197195 Free PMC article.
T cell toxicity of HIV latency reversing agents.
Zhao M, De Crignis E, Rokx C, Verbon A, van Gelder T, Mahmoudi T, Katsikis PD, Mueller YM. Zhao M, et al. Among authors: mahmoudi t. Pharmacol Res. 2019 Jan;139:524-534. doi: 10.1016/j.phrs.2018.10.023. Epub 2018 Oct 23. Pharmacol Res. 2019. PMID: 30366100
140 results