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A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours.
Br J Cancer. 2020 Nov;123(10):1481-1489. doi: 10.1038/s41416-020-01028-8. Epub 2020 Aug 25.
Br J Cancer. 2020.
PMID: 32839491
Free PMC article.
Clinical Trial.
Evidence of antiangiogenic and antimetastatic activities of the recombinant disintegrin domain of metargidin.
Trochon-Joseph V, Martel-Renoir D, Mir LM, Thomaïdis A, Opolon P, Connault E, Li H, Grenet C, Fauvel-Lafève F, Soria J, Legrand C, Soria C, Perricaudet M, Lu H.
Trochon-Joseph V, et al.
Cancer Res. 2004 Mar 15;64(6):2062-9. doi: 10.1158/0008-5472.can-03-3272.
Cancer Res. 2004.
PMID: 15026344
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Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model.
Llopiz D, Ruiz M, Villanueva L, Iglesias T, Silva L, Egea J, Lasarte JJ, Pivette P, Trochon-Joseph V, Vasseur B, Dixon G, Sangro B, Sarobe P.
Llopiz D, et al. Among authors: trochon joseph v.
Cancer Immunol Immunother. 2019 Mar;68(3):379-393. doi: 10.1007/s00262-018-2283-0. Epub 2018 Dec 13.
Cancer Immunol Immunother. 2019.
PMID: 30547218
Free PMC article.
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Coelectrotransfer to skeletal muscle of three plasmids coding for antiangiogenic factors and regulatory factors of the tetracycline-inducible system: tightly regulated expression, inhibition of transplanted tumor growth, and antimetastatic effect.
Martel-Renoir D, Trochon-Joseph V, Galaup A, Bouquet C, Griscelli F, Opolon P, Opolon D, Connault E, Mir L, Perricaudet M.
Martel-Renoir D, et al. Among authors: trochon joseph v.
Mol Ther. 2003 Sep;8(3):425-33. doi: 10.1016/s1525-0016(03)00201-6.
Mol Ther. 2003.
PMID: 12946315
Free article.
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Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions.
Zibert JR, Wallbrecht K, Schön M, Mir LM, Jacobsen GK, Trochon-Joseph V, Bouquet C, Villadsen LS, Cadossi R, Skov L, Schön MP.
Zibert JR, et al. Among authors: trochon joseph v.
J Clin Invest. 2011 Jan;121(1):410-21. doi: 10.1172/JCI41295. Epub 2010 Dec 6.
J Clin Invest. 2011.
PMID: 21135506
Free PMC article.
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