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β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus.
Zhang M, Lai Y, Krupalnik V, Guo P, Guo X, Zhou J, Xu Y, Yu Z, Liu L, Jiang A, Li W, Abdul MM, Ma G, Li N, Fu X, Lv Y, Jiang M, Tariq M, Kanwal S, Liu H, Xu X, Zhang H, Huang Y, Wang L, Chen S, Babarinde IA, Luo Z, Wang D, Zhou T, Ward C, He M, Ibañez DP, Li Y, Zhou J, Yuan J, Feng Y, Arumugam K, Di Vicino U, Bao X, Wu G, Schambach A, Wang H, Sun H, Gao F, Qin B, Hutchins AP, Doble BW, Hartmann C, Cosma MP, Qin Y, Xu GL, Chen R, Volpe G, Chen L, Hanna JH, Esteban MA. Zhang M, et al. Among authors: hutchins ap. Sci Adv. 2020 Jul 17;6(29):eaba1593. doi: 10.1126/sciadv.aba1593. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32832621 Free PMC article.
Transcriptional pause release is a rate-limiting step for somatic cell reprogramming.
Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA. Liu L, et al. Among authors: hutchins ap. Cell Stem Cell. 2014 Nov 6;15(5):574-88. doi: 10.1016/j.stem.2014.09.018. Epub 2014 Oct 9. Cell Stem Cell. 2014. PMID: 25312495 Free article.
The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters.
Bao X, Wu H, Zhu X, Guo X, Hutchins AP, Luo Z, Song H, Chen Y, Lai K, Yin M, Xu L, Zhou L, Chen J, Wang D, Qin B, Frampton J, Tse HF, Pei D, Wang H, Zhang B, Esteban MA. Bao X, et al. Among authors: hutchins ap. Cell Res. 2015 Jan;25(1):80-92. doi: 10.1038/cr.2014.165. Epub 2014 Dec 16. Cell Res. 2015. PMID: 25512341 Free PMC article.
Transcriptional Control of Somatic Cell Reprogramming.
Xu Y, Zhang M, Li W, Zhu X, Bao X, Qin B, Hutchins AP, Esteban MA. Xu Y, et al. Among authors: hutchins ap. Trends Cell Biol. 2016 Apr;26(4):272-288. doi: 10.1016/j.tcb.2015.12.003. Epub 2016 Jan 15. Trends Cell Biol. 2016. PMID: 26776886 Review.
RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.
Li H, Lai P, Jia J, Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Dong X, Zhao J, Hou C, Esteban MA, Gao S, Pei D, Hutchins AP, Yao H. Li H, et al. Among authors: hutchins ap. Cell Stem Cell. 2017 Apr 6;20(4):462-477.e6. doi: 10.1016/j.stem.2016.12.002. Epub 2017 Jan 19. Cell Stem Cell. 2017. PMID: 28111200 Free article.
Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells.
Yang J, Wang Y, Zhou T, Wong LY, Tian XY, Hong X, Lai WH, Au KW, Wei R, Liu Y, Cheng LH, Liang G, Huang Z, Fan W, Zhao P, Wang X, Ibañez DP, Luo Z, Li Y, Zhong X, Chen S, Wang D, Li L, Lai L, Qin B, Bao X, Hutchins AP, Siu CW, Huang Y, Esteban MA, Tse HF. Yang J, et al. Among authors: hutchins ap. Stem Cell Reports. 2017 Mar 14;8(3):605-618. doi: 10.1016/j.stemcr.2017.01.027. Epub 2017 Mar 2. Stem Cell Reports. 2017. PMID: 28262545 Free PMC article.
Capturing the interactome of newly transcribed RNA.
Bao X, Guo X, Yin M, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, Li N, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, Zhang C, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B, Esteban MA. Bao X, et al. Among authors: hutchins ap. Nat Methods. 2018 Mar;15(3):213-220. doi: 10.1038/nmeth.4595. Epub 2018 Feb 12. Nat Methods. 2018. PMID: 29431736 Free PMC article.
NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.
Zhuang Q, Li W, Benda C, Huang Z, Ahmed T, Liu P, Guo X, Ibañez DP, Luo Z, Zhang M, Abdul MM, Yang Z, Yang J, Huang Y, Zhang H, Huang D, Zhou J, Zhong X, Zhu X, Fu X, Fan W, Liu Y, Xu Y, Ward C, Khan MJ, Kanwal S, Mirza B, Tortorella MD, Tse HF, Chen J, Qin B, Bao X, Gao S, Hutchins AP, Esteban MA. Zhuang Q, et al. Among authors: hutchins ap. Nat Cell Biol. 2018 Apr;20(4):400-412. doi: 10.1038/s41556-018-0047-x. Epub 2018 Mar 12. Nat Cell Biol. 2018. PMID: 29531310
85 results