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De novo active sites for resurrected Precambrian enzymes.
Risso VA, Martinez-Rodriguez S, Candel AM, Krüger DM, Pantoja-Uceda D, Ortega-Muñoz M, Santoyo-Gonzalez F, Gaucher EA, Kamerlin SCL, Bruix M, Gavira JA, Sanchez-Ruiz JM. Risso VA, et al. Among authors: kamerlin scl. Nat Commun. 2017 Jul 18;8:16113. doi: 10.1038/ncomms16113. Nat Commun. 2017. PMID: 28719578 Free PMC article.
Cooperativity and flexibility in enzyme evolution.
Pabis A, Risso VA, Sanchez-Ruiz JM, Kamerlin SC. Pabis A, et al. Curr Opin Struct Biol. 2018 Feb;48:83-92. doi: 10.1016/j.sbi.2017.10.020. Epub 2017 Nov 12. Curr Opin Struct Biol. 2018. PMID: 29141202 Free article. Review.
Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase.
Gamiz-Arco G, Gutierrez-Rus LI, Risso VA, Ibarra-Molero B, Hoshino Y, Petrović D, Justicia J, Cuerva JM, Romero-Rivera A, Seelig B, Gavira JA, Kamerlin SCL, Gaucher EA, Sanchez-Ruiz JM. Gamiz-Arco G, et al. Among authors: kamerlin scl. Nat Commun. 2021 Jan 15;12(1):380. doi: 10.1038/s41467-020-20630-1. Nat Commun. 2021. PMID: 33452262 Free PMC article.
148 results