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Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations.
Gintant G, Kaushik EP, Feaster T, Stoelzle-Feix S, Kanda Y, Osada T, Smith G, Czysz K, Kettenhofen R, Lu HR, Cai B, Shi H, Herron TJ, Dang Q, Burton F, Pang L, Traebert M, Abassi Y, Pierson JB, Blinova K. Gintant G, et al. Regul Toxicol Pharmacol. 2020 Nov;117:104756. doi: 10.1016/j.yrtph.2020.104756. Epub 2020 Aug 19. Regul Toxicol Pharmacol. 2020. PMID: 32822771 Free article. Review.
International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment.
Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G. Blinova K, et al. Among authors: gintant g. Cell Rep. 2018 Sep 25;24(13):3582-3592. doi: 10.1016/j.celrep.2018.08.079. Cell Rep. 2018. PMID: 30257217 Free PMC article.
Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study.
Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G. Millard D, et al. Among authors: gintant g. Toxicol Sci. 2018 Aug 1;164(2):550-562. doi: 10.1093/toxsci/kfy110. Toxicol Sci. 2018. PMID: 29718449 Free PMC article.
The Use of Ratiometric Fluorescence Measurements of the Voltage Sensitive Dye Di-4-ANEPPS to Examine Action Potential Characteristics and Drug Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Hortigon-Vinagre MP, Zamora V, Burton FL, Green J, Gintant GA, Smith GL. Hortigon-Vinagre MP, et al. Among authors: gintant ga. Toxicol Sci. 2016 Dec;154(2):320-331. doi: 10.1093/toxsci/kfw171. Epub 2016 Sep 11. Toxicol Sci. 2016. PMID: 27621282 Free PMC article.
Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms.
Pfeiffer-Kaushik ER, Smith GL, Cai B, Dempsey GT, Hortigon-Vinagre MP, Zamora V, Feng S, Ingermanson R, Zhu R, Hariharan V, Nguyen C, Pierson J, Gintant GA, Tung L. Pfeiffer-Kaushik ER, et al. J Pharmacol Toxicol Methods. 2019 Sep-Oct;99:106612. doi: 10.1016/j.vascn.2019.106612. Epub 2019 Jul 15. J Pharmacol Toxicol Methods. 2019. PMID: 31319140 Free article.
Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes.
Ribeiro AJS, Guth BD, Engwall M, Eldridge S, Foley CM, Guo L, Gintant G, Koerner J, Parish ST, Pierson JB, Brock M, Chaudhary KW, Kanda Y, Berridge B. Ribeiro AJS, et al. Among authors: gintant g. Front Pharmacol. 2019 Aug 29;10:934. doi: 10.3389/fphar.2019.00934. eCollection 2019. Front Pharmacol. 2019. PMID: 31555128 Free PMC article. Review.
105 results