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C57BL/6J substrain differences in response to high-fat diet intervention.
Siersbæk MS, Ditzel N, Hejbøl EK, Præstholm SM, Markussen LK, Avolio F, Li L, Lehtonen L, Hansen AK, Schrøder HD, Krych L, Mandrup S, Langhorn L, Bollen P, Grøntved L. Siersbæk MS, et al. Among authors: markussen lk. Sci Rep. 2020 Aug 20;10(1):14052. doi: 10.1038/s41598-020-70765-w. Sci Rep. 2020. PMID: 32820201 Free PMC article.
Lipolysis regulates major transcriptional programs in brown adipocytes.
Markussen LK, Rondini EA, Johansen OS, Madsen JGS, Sustarsic EG, Marcher AB, Hansen JB, Gerhart-Hines Z, Granneman JG, Mandrup S. Markussen LK, et al. Nat Commun. 2022 Jul 8;13(1):3956. doi: 10.1038/s41467-022-31525-8. Nat Commun. 2022. PMID: 35803907 Free PMC article.
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Sveidahl Johansen O, Ma T, Hansen JB, Markussen LK, Schreiber R, Reverte-Salisa L, Dong H, Christensen DP, Sun W, Gnad T, Karavaeva I, Nielsen TS, Kooijman S, Cero C, Dmytriyeva O, Shen Y, Razzoli M, O'Brien SL, Kuipers EN, Nielsen CH, Orchard W, Willemsen N, Jespersen NZ, Lundh M, Sustarsic EG, Hallgren CM, Frost M, McGonigle S, Isidor MS, Broholm C, Pedersen O, Hansen JB, Grarup N, Hansen T, Kjær A, Granneman JG, Babu MM, Calebiro D, Nielsen S, Rydén M, Soccio R, Rensen PCN, Treebak JT, Schwartz TW, Emanuelli B, Bartolomucci A, Pfeifer A, Zechner R, Scheele C, Mandrup S, Gerhart-Hines Z. Sveidahl Johansen O, et al. Among authors: markussen lk. Cell. 2021 Jun 24;184(13):3502-3518.e33. doi: 10.1016/j.cell.2021.04.037. Epub 2021 May 27. Cell. 2021. PMID: 34048700 Free PMC article.
Metformin targets brown adipose tissue in vivo and reduces oxygen consumption in vitro.
Breining P, Jensen JB, Sundelin EI, Gormsen LC, Jakobsen S, Busk M, Rolighed L, Bross P, Fernandez-Guerra P, Markussen LK, Rasmussen NE, Hansen JB, Pedersen SB, Richelsen B, Jessen N. Breining P, et al. Among authors: markussen lk. Diabetes Obes Metab. 2018 Sep;20(9):2264-2273. doi: 10.1111/dom.13362. Epub 2018 Jun 8. Diabetes Obes Metab. 2018. PMID: 29752759
Pyruvate kinase M2 represses thermogenic gene expression in brown adipocytes.
Isidor MS, Winther S, Markussen LK, Basse AL, Quistorff B, Nedergaard J, Emanuelli B, Hansen JB. Isidor MS, et al. Among authors: markussen lk. FEBS Lett. 2020 Apr;594(7):1218-1225. doi: 10.1002/1873-3468.13716. Epub 2019 Dec 20. FEBS Lett. 2020. PMID: 31823361 Free article.