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Introduction of Scaffold Nitrogen Atoms Renders Inhibitors of the Malarial l-Lactate Transporter, PfFNT, Effective against the Gly107Ser Resistance Mutation.
J Med Chem. 2020 Sep 10;63(17):9731-9741. doi: 10.1021/acs.jmedchem.0c00852. Epub 2020 Aug 28.
J Med Chem. 2020.
PMID: 32816478
Pentafluoro-3-hydroxy-pent-2-en-1-ones Potently Inhibit FNT-Type Lactate Transporters from all Five Human-Pathogenic Plasmodium Species.
Walloch P, Hansen C, Priegann T, Schade D, Beitz E.
Walloch P, et al.
ChemMedChem. 2021 Apr 20;16(8):1283-1289. doi: 10.1002/cmdc.202000952. Epub 2021 Feb 1.
ChemMedChem. 2021.
PMID: 33336890
Free PMC article.
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Aquaporins with lactate/lactic acid permeability at physiological pH conditions.
Schmidt JDR, Walloch P, Höger B, Beitz E.
Schmidt JDR, et al. Among authors: walloch p.
Biochimie. 2021 Sep;188:7-11. doi: 10.1016/j.biochi.2021.01.018. Epub 2021 Feb 10.
Biochimie. 2021.
PMID: 33577940
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The Plasmodium Lactate/H+ Transporter PfFNT Is Essential and Druggable In Vivo.
Davies H, Bergmann B, Walloch P, Nerlich C, Hansen C, Wittlin S, Spielmann T, Treeck M, Beitz E.
Davies H, et al. Among authors: walloch p.
Antimicrob Agents Chemother. 2023 Aug 17;67(8):e0035623. doi: 10.1128/aac.00356-23. Epub 2023 Jul 10.
Antimicrob Agents Chemother. 2023.
PMID: 37428074
Free PMC article.
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