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A genetic system to study Plasmodium falciparum protein function.
Birnbaum J, Flemming S, Reichard N, Soares AB, Mesén-Ramírez P, Jonscher E, Bergmann B, Spielmann T. Birnbaum J, et al. Among authors: spielmann t. Nat Methods. 2017 Apr;14(4):450-456. doi: 10.1038/nmeth.4223. Epub 2017 Mar 13. Nat Methods. 2017. PMID: 28288121
PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites.
Jonscher E, Flemming S, Schmitt M, Sabitzki R, Reichard N, Birnbaum J, Bergmann B, Höhn K, Spielmann T. Jonscher E, et al. Among authors: spielmann t. Cell Host Microbe. 2019 Jan 9;25(1):166-173.e5. doi: 10.1016/j.chom.2018.11.010. Epub 2018 Dec 20. Cell Host Microbe. 2019. PMID: 30581113 Free article.
A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites.
Birnbaum J, Scharf S, Schmidt S, Jonscher E, Hoeijmakers WAM, Flemming S, Toenhake CG, Schmitt M, Sabitzki R, Bergmann B, Fröhlke U, Mesén-Ramírez P, Blancke Soares A, Herrmann H, Bártfai R, Spielmann T. Birnbaum J, et al. Among authors: spielmann t. Science. 2020 Jan 3;367(6473):51-59. doi: 10.1126/science.aax4735. Science. 2020. PMID: 31896710
The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost.
Mesén-Ramírez P, Bergmann B, Elhabiri M, Zhu L, von Thien H, Castro-Peña C, Gilberger TW, Davioud-Charvet E, Bozdech Z, Bachmann A, Spielmann T. Mesén-Ramírez P, et al. Among authors: spielmann t. Cell Host Microbe. 2021 Dec 8;29(12):1774-1787.e9. doi: 10.1016/j.chom.2021.11.002. Epub 2021 Dec 3. Cell Host Microbe. 2021. PMID: 34863371 Free article.
88 results