Treherne JM - Search Results

1

Novel hydrogels: are they poised to transform 3D cell-based assay systems in early drug discovery?

Treherne JM, Miller AF. Treherne JM, et al. Expert Opin Drug Discov. 2023 Mar;18(3):335-346. doi: 10.1080/17460441.2023.2175813. Epub 2023 Feb 7. Expert Opin Drug Discov. 2023. PMID: 36722285

2

Predictive validity in drug discovery: what it is, why it matters and how to improve it.

Scannell JW, Bosley J, Hickman JA, Dawson GR, Truebel H, Ferreira GS, Richards D, Treherne JM. Scannell JW, et al. Among authors: treherne jm. Nat Rev Drug Discov. 2022 Dec;21(12):915-931. doi: 10.1038/s41573-022-00552-x. Epub 2022 Oct 4. Nat Rev Drug Discov. 2022. PMID: 36195754 Review.

3

Converging global crises are forcing the rapid adoption of disruptive changes in drug discovery.

Treherne JM, Langley GR. Treherne JM, et al. Drug Discov Today. 2021 Nov;26(11):2489-2495. doi: 10.1016/j.drudis.2021.05.001. Epub 2021 May 18. Drug Discov Today. 2021. PMID: 34015541 Free PMC article.

4

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors.

Badder LM, Hollins AJ, Herpers B, Yan K, Ewan KB, Thomas M, Shone JR, Badder DA, Naven M, Ashelford KE, Hargest R, Clarke AR, Esdar C, Buchstaller HP, Treherne JM, Boj S, Ramezanpour B, Wienke D, Price LS, Shaw PH, Dale TC. Badder LM, et al. Among authors: treherne jm. PLoS One. 2020 Aug 18;15(8):e0235319. doi: 10.1371/journal.pone.0235319. eCollection 2020. PLoS One. 2020. PMID: 32810173 Free PMC article.

5

SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer's disease.

Brunner D, Flunkert S, Neddens J, Duller S, Scopes DIC, Treherne JM, Hutter-Paier B. Brunner D, et al. Among authors: treherne jm. Neurosci Lett. 2017 Nov 1;660:96-102. doi: 10.1016/j.neulet.2017.09.028. Epub 2017 Sep 14. Neurosci Lett. 2017. PMID: 28917978

6

Novel 5-aryloxypyrimidine SEN1576 as a candidate for the treatment of Alzheimer's disease.

O'Hare E, Scopes DI, Kim EM, Palmer P, Spanswick D, McMahon B, Amijee H, Nerou E, Treherne JM, Jeggo R. O'Hare E, et al. Among authors: treherne jm. Int J Neuropsychopharmacol. 2014 Jan;17(1):117-26. doi: 10.1017/S1461145713000886. Epub 2013 Oct 8. Int J Neuropsychopharmacol. 2014. PMID: 24103729 Free article.

7

Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500.

Lo AC, Tesseur I, Scopes DI, Nerou E, Callaerts-Vegh Z, Vermaercke B, Treherne JM, De Strooper B, D'Hooge R. Lo AC, et al. Among authors: treherne jm. Neuropharmacology. 2013 Dec;75:458-66. doi: 10.1016/j.neuropharm.2013.08.030. Epub 2013 Sep 10. Neuropharmacology. 2013. PMID: 24035915

8

Orally bioavailable small molecule drug protects memory in Alzheimer's disease models.

O'Hare E, Scopes DI, Kim EM, Palmer P, Jones M, Whyment AD, Spanswick D, Amijee H, Nerou E, McMahon B, Treherne JM, Jeggo R. O'Hare E, et al. Among authors: treherne jm. Neurobiol Aging. 2013 Apr;34(4):1116-25. doi: 10.1016/j.neurobiolaging.2012.10.016. Epub 2012 Nov 17. Neurobiol Aging. 2013. PMID: 23164690

9

The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation.

Amijee H, Bate C, Williams A, Virdee J, Jeggo R, Spanswick D, Scopes DI, Treherne JM, Mazzitelli S, Chawner R, Eyers CE, Doig AJ. Amijee H, et al. Among authors: treherne jm. Biochemistry. 2012 Oct 23;51(42):8338-52. doi: 10.1021/bi300415v. Epub 2012 Oct 12. Biochemistry. 2012. PMID: 23025847

10

Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity.

Scopes DI, O'Hare E, Jeggo R, Whyment AD, Spanswick D, Kim EM, Gannon J, Amijee H, Treherne JM. Scopes DI, et al. Among authors: treherne jm. Br J Pharmacol. 2012 Sep;167(2):383-92. doi: 10.1111/j.1476-5381.2012.01973.x. Br J Pharmacol. 2012. PMID: 22913627 Free PMC article.

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