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The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice.
Petruzziello-Pellegrini TN, Yuen DA, Page AV, Patel S, Soltyk AM, Matouk CC, Wong DK, Turgeon PJ, Fish JE, Ho JJ, Steer BM, Khajoee V, Tigdi J, Lee WL, Motto DG, Advani A, Gilbert RE, Karumanchi SA, Robinson LA, Tarr PI, Liles WC, Brunton JL, Marsden PA. Petruzziello-Pellegrini TN, et al. Among authors: patel s. J Clin Invest. 2012 Feb;122(2):759-76. doi: 10.1172/JCI57313. Epub 2012 Jan 9. J Clin Invest. 2012. PMID: 22232208 Free PMC article.
The cell motility modulator Slit2 is a potent inhibitor of platelet function.
Patel S, Huang YW, Reheman A, Pluthero FG, Chaturvedi S, Mukovozov IM, Tole S, Liu GY, Li L, Durocher Y, Ni H, Kahr WH, Robinson LA. Patel S, et al. Circulation. 2012 Sep 11;126(11):1385-95. doi: 10.1161/CIRCULATIONAHA.112.105452. Epub 2012 Aug 3. Circulation. 2012. PMID: 22865890
The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus.
Bhosle VK, Sun C, Patel S, Ho TWW, Westman J, Ammendolia DA, Langari FM, Fine N, Toepfner N, Li Z, Sharma M, Glogauer J, Capurro MI, Jones NL, Maynes JT, Lee WL, Glogauer M, Grinstein S, Robinson LA. Bhosle VK, et al. Among authors: patel s. Elife. 2023 Sep 29;12:e87392. doi: 10.7554/eLife.87392. Elife. 2023. PMID: 37773612 Free PMC article.
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