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An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.
Zafra MP, Parsons MJ, Kim J, Alonso-Curbelo D, Goswami S, Schatoff EM, Han T, Katti A, Fernandez MTC, Wilkinson JE, Piskounova E, Dow LE. Zafra MP, et al. Among authors: dow le. Cancer Discov. 2020 Nov;10(11):1654-1671. doi: 10.1158/2159-8290.CD-20-0442. Epub 2020 Aug 12. Cancer Discov. 2020. PMID: 32792368 Free PMC article.
A modular and flexible ESC-based mouse model of pancreatic cancer.
Saborowski M, Saborowski A, Morris JP 4th, Bosbach B, Dow LE, Pelletier J, Klimstra DS, Lowe SW. Saborowski M, et al. Among authors: dow le. Genes Dev. 2014 Jan 1;28(1):85-97. doi: 10.1101/gad.232082.113. Genes Dev. 2014. PMID: 24395249 Free PMC article.
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC. Yun J, et al. Among authors: dow le. Science. 2015 Dec 11;350(6266):1391-6. doi: 10.1126/science.aaa5004. Epub 2015 Nov 5. Science. 2015. PMID: 26541605 Free PMC article.
Somatic Genome Editing Goes Viral.
Zafra MP, Dow LE. Zafra MP, et al. Among authors: dow le. Trends Mol Med. 2016 Oct;22(10):831-833. doi: 10.1016/j.molmed.2016.08.004. Epub 2016 Aug 20. Trends Mol Med. 2016. PMID: 27555346 Free PMC article.
Wnt Signaling and Colorectal Cancer.
Schatoff EM, Leach BI, Dow LE. Schatoff EM, et al. Among authors: dow le. Curr Colorectal Cancer Rep. 2017 Apr;13(2):101-110. doi: 10.1007/s11888-017-0354-9. Epub 2017 Feb 28. Curr Colorectal Cancer Rep. 2017. PMID: 28413363 Free PMC article.
Optimized base editors enable efficient editing in cells, organoids and mice.
Zafra MP, Schatoff EM, Katti A, Foronda M, Breinig M, Schweitzer AY, Simon A, Han T, Goswami S, Montgomery E, Thibado J, Kastenhuber ER, Sánchez-Rivera FJ, Shi J, Vakoc CR, Lowe SW, Tschaharganeh DF, Dow LE. Zafra MP, et al. Among authors: dow le. Nat Biotechnol. 2018 Oct;36(9):888-893. doi: 10.1038/nbt.4194. Epub 2018 Jul 3. Nat Biotechnol. 2018. PMID: 29969439 Free PMC article.
86 results