Hailes HC - Search Results

1

Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis.

Maitra A, Evangelopoulos D, Chrzastek A, Martin LT, Hanrath A, Chapman E, Hailes HC, Lipman M, McHugh TD, Waddell SJ, Bhakta S. Maitra A, et al. Among authors: hailes hc. J Antimicrob Chemother. 2020 Nov 1;75(11):3194-3201. doi: 10.1093/jac/dkaa307. J Antimicrob Chemother. 2020. PMID: 32790867 Free PMC article.

2

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase.

Guzman JD, Pesnot T, Barrera DA, Davies HM, McMahon E, Evangelopoulos D, Mortazavi PN, Munshi T, Maitra A, Lamming ED, Angell R, Gershater MC, Redmond JM, Needham D, Ward JM, Cuca LE, Hailes HC, Bhakta S. Guzman JD, et al. Among authors: hailes hc. J Antimicrob Chemother. 2015;70(6):1691-703. doi: 10.1093/jac/dkv010. Epub 2015 Feb 4. J Antimicrob Chemother. 2015. PMID: 25656411 Free PMC article.

3

Catalytic direct amidations in tert-butyl acetate using B(OCH₂CF₃)₃.

Coomber CE, Laserna V, Martin LT, Smith PD, Hailes HC, Porter MJ, Sheppard TD. Coomber CE, et al. Among authors: hailes hc. Org Biomol Chem. 2019 Jul 14;17(26):6465-6469. doi: 10.1039/c9ob01012b. Epub 2019 Jun 21. Org Biomol Chem. 2019. PMID: 31225568 Free PMC article.

4

Antimycobacterial calixarenes enhance innate defense mechanisms in murine macrophages and induce control of Mycobacterium tuberculosis infection in mice.

Colston MJ, Hailes HC, Stavropoulos E, Hervé AC, Hervé G, Goodworth KJ, Hill AM, Jenner P, Hart PD, Tascon RE. Colston MJ, et al. Among authors: hailes hc. Infect Immun. 2004 Nov;72(11):6318-23. doi: 10.1128/IAI.72.11.6318-6323.2004. Infect Immun. 2004. PMID: 15501760 Free PMC article.

5

Facile and selective N-alkylation of gentamicin antibiotics via chemoenzymatic synthesis.

Stojanovski G, Hailes HC, Ward JM. Stojanovski G, et al. Among authors: hailes hc. Green Chem. 2022 Nov 17;24(24):9542-9551. doi: 10.1039/d2gc03600b. eCollection 2022 Dec 12. Green Chem. 2022. PMID: 36544494 Free PMC article.

6

Directed evolution of biocatalytic processes.

Hibbert EG, Baganz F, Hailes HC, Ward JM, Lye GJ, Woodley JM, Dalby PA. Hibbert EG, et al. Among authors: hailes hc. Biomol Eng. 2005 Jun;22(1-3):11-9. doi: 10.1016/j.bioeng.2004.09.003. Biomol Eng. 2005. PMID: 15857779 Review.

7

A colorimetric assay for screening transketolase activity.

Smith ME, Kaulmann U, Ward JM, Hailes HC. Smith ME, et al. Among authors: hailes hc. Bioorg Med Chem. 2006 Oct 15;14(20):7062-5. doi: 10.1016/j.bmc.2006.06.008. Epub 2006 Jun 19. Bioorg Med Chem. 2006. PMID: 16784864

8

One-pot synthesis of amino-alcohols using a de-novo transketolase and beta-alanine: pyruvate transaminase pathway in Escherichia coli.

Ingram CU, Bommer M, Smith ME, Dalby PA, Ward JM, Hailes HC, Lye GJ. Ingram CU, et al. Among authors: hailes hc. Biotechnol Bioeng. 2007 Feb 15;96(3):559-69. doi: 10.1002/bit.21125. Biotechnol Bioeng. 2007. PMID: 16902948

9

Directed evolution of transketolase activity on non-phosphorylated substrates.

Hibbert EG, Senussi T, Costelloe SJ, Lei W, Smith ME, Ward JM, Hailes HC, Dalby PA. Hibbert EG, et al. Among authors: hailes hc. J Biotechnol. 2007 Sep 30;131(4):425-32. doi: 10.1016/j.jbiotec.2007.07.949. Epub 2007 Aug 3. J Biotechnol. 2007. PMID: 17825449

10

Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde.

Hibbert EG, Senussi T, Smith ME, Costelloe SJ, Ward JM, Hailes HC, Dalby PA. Hibbert EG, et al. Among authors: hailes hc. J Biotechnol. 2008 Apr 30;134(3-4):240-5. doi: 10.1016/j.jbiotec.2008.01.018. Epub 2008 Feb 13. J Biotechnol. 2008. PMID: 18342970

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