Holden K - Search Results

1

ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae.

Davies DT, Leiris S, Sprynski N, Castandet J, Lozano C, Bousquet J, Zalacain M, Vasa S, Dasari PK, Pattipati R, Vempala N, Gujjewar S, Godi S, Jallala R, Sathyap RR, Darshanoju NA, Ravu VR, Juventhala RR, Pottabathini N, Sharma S, Pothukanuri S, Holden K, Warn P, Marcoccia F, Benvenuti M, Pozzi C, Mangani S, Docquier JD, Lemonnier M, Everett M. Davies DT, et al. Among authors: holden k. ACS Infect Dis. 2020 Sep 11;6(9):2419-2430. doi: 10.1021/acsinfecdis.0c00207. Epub 2020 Aug 20. ACS Infect Dis. 2020. PMID: 32786279

2

Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae.

Everett M, Sprynski N, Coelho A, Castandet J, Bayet M, Bougnon J, Lozano C, Davies DT, Leiris S, Zalacain M, Morrissey I, Magnet S, Holden K, Warn P, De Luca F, Docquier JD, Lemonnier M. Everett M, et al. Among authors: holden k. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00074-18. doi: 10.1128/AAC.00074-18. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29530861 Free PMC article.

3

Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii.

Davies DT, Leiris S, Zalacain M, Sprynski N, Castandet J, Bousquet J, Lozano C, Llanos A, Alibaud L, Vasa S, Pattipati R, Valige R, Kummari B, Pothukanuri S, De Piano C, Morrissey I, Holden K, Warn P, Marcoccia F, Benvenuti M, Pozzi C, Tassone G, Mangani S, Docquier JD, Pallin D, Elliot R, Lemonnier M, Everett M. Davies DT, et al. Among authors: holden k. J Med Chem. 2020 Dec 24;63(24):15802-15820. doi: 10.1021/acs.jmedchem.0c01535. Epub 2020 Dec 11. J Med Chem. 2020. PMID: 33306385

4

Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity.

Hertzberg RP, Caranfa MJ, Holden KG, Jakas DR, Gallagher G, Mattern MR, Mong SM, Bartus JO, Johnson RK, Kingsbury WD. Hertzberg RP, et al. Among authors: holden kg. J Med Chem. 1989 Mar;32(3):715-20. doi: 10.1021/jm00123a038. J Med Chem. 1989. PMID: 2537428

5

Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 2.

Kruse CH, Holden KG, Offen PH, Pritchard ML, Feild JA, Rieman DJ, Bender PE, Ferguson B, Greig RG, Poste G. Kruse CH, et al. Among authors: holden kg. J Med Chem. 1988 Sep;31(9):1768-72. doi: 10.1021/jm00117a016. J Med Chem. 1988. PMID: 3045321

6

6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics.

Kaiser C, Ali FE, Bondinell WE, Brenner M, Holden KG, Ku TW, Oh HJ, Ross ST, Yim NC, Zirkle CL, Hahn RA, Sarau HM, Setler PE, Wardell JR Jr. Kaiser C, et al. Among authors: holden kg. J Med Chem. 1980 Sep;23(9):975-6. doi: 10.1021/jm00183a002. J Med Chem. 1980. PMID: 6106062 No abstract available.

7

Nuclear analogues of beta-lactam antibiotics. 4. Total synthesis of bisnorisopenicillins from beta-lactam precursors.

Huffman WF, Hall RF, Grant JA, Holden KG. Huffman WF, et al. Among authors: holden kg. J Med Chem. 1978 May;21(5):413-5. doi: 10.1021/jm00203a001. J Med Chem. 1978. PMID: 660583 No abstract available.

8

Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 1.

Kruse CH, Holden KG, Pritchard ML, Feild JA, Rieman DJ, Greig RG, Poste G. Kruse CH, et al. Among authors: holden kg. J Med Chem. 1988 Sep;31(9):1762-7. doi: 10.1021/jm00117a015. J Med Chem. 1988. PMID: 2970550

9

Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.

Kingsbury WD, Boehm JC, Jakas DR, Holden KG, Hecht SM, Gallagher G, Caranfa MJ, McCabe FL, Faucette LF, Johnson RK, et al. Kingsbury WD, et al. Among authors: holden kg. J Med Chem. 1991 Jan;34(1):98-107. doi: 10.1021/jm00105a017. J Med Chem. 1991. PMID: 1846923

10

Development of an affinity ligand for purification of alpha 2-adrenoceptors from human platelet membranes.

DeMarinis RM, Krog AJ, Shah DH, Lafferty J, Holden KG, Hieble JP, Matthews WD, Regan JW, Lefkowitz RJ, Caron MG. DeMarinis RM, et al. Among authors: holden kg. J Med Chem. 1984 Jul;27(7):918-21. doi: 10.1021/jm00373a018. J Med Chem. 1984. PMID: 6330361

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