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Simultaneous activation of the small conductance calcium-activated potassium current by acetylcholine and inhibition of sodium current by ajmaline cause J-wave syndrome in Langendorff-perfused rabbit ventricles.
Fei YD, Chen M, Guo S, Ueoka A, Chen Z, Rubart-von der Lohe M, Everett TH 4th, Qu Z, Weiss JN, Chen PS. Fei YD, et al. Among authors: guo s. Heart Rhythm. 2021 Jan;18(1):98-108. doi: 10.1016/j.hrthm.2020.07.036. Epub 2020 Aug 4. Heart Rhythm. 2021. PMID: 32763429 Free PMC article.
Ondansetron blocks wild-type and p.F503L variant small-conductance Ca2+-activated K+ channels.
Ko JS, Guo S, Hassel J, Celestino-Soper P, Lynnes TC, Tisdale JE, Zheng JJ, Taylor SE, Foroud T, Murray MD, Kovacs RJ, Li X, Lin SF, Chen Z, Vatta M, Chen PS, Rubart M. Ko JS, et al. Among authors: guo s. Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H375-H388. doi: 10.1152/ajpheart.00479.2017. Epub 2018 Apr 20. Am J Physiol Heart Circ Physiol. 2018. PMID: 29677462 Free PMC article.
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