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A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study.
Harrison SA, Ratziu V, Boursier J, Francque S, Bedossa P, Majd Z, Cordonnier G, Sudrik FB, Darteil R, Liebe R, Magnanensi J, Hajji Y, Brozek J, Roudot A, Staels B, Hum DW, Megnien SJ, Hosmane S, Dam N, Chaumat P, Hanf R, Anstee QM, Sanyal AJ. Harrison SA, et al. Among authors: hum dw. Lancet Gastroenterol Hepatol. 2020 Nov;5(11):970-985. doi: 10.1016/S2468-1253(20)30252-1. Epub 2020 Aug 5. Lancet Gastroenterol Hepatol. 2020. PMID: 32763196 Clinical Trial.
Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.
Ratziu V, Harrison SA, Francque S, Bedossa P, Lehert P, Serfaty L, Romero-Gomez M, Boursier J, Abdelmalek M, Caldwell S, Drenth J, Anstee QM, Hum D, Hanf R, Roudot A, Megnien S, Staels B, Sanyal A; GOLDEN-505 Investigator Study Group. Ratziu V, et al. Gastroenterology. 2016 May;150(5):1147-1159.e5. doi: 10.1053/j.gastro.2016.01.038. Epub 2016 Feb 11. Gastroenterology. 2016. PMID: 26874076 Free article. Clinical Trial.
Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, Millatt LJ, Baron M, Lucas A, Tailleux A, Hum DW, Ratziu V, Cariou B, Hanf R. Staels B, et al. Among authors: hum dw. Hepatology. 2013 Dec;58(6):1941-52. doi: 10.1002/hep.26461. Epub 2013 Oct 29. Hepatology. 2013. PMID: 23703580 Clinical Trial.
Safety issues and prospects for future generations of PPAR modulators.
Rubenstrunk A, Hanf R, Hum DW, Fruchart JC, Staels B. Rubenstrunk A, et al. Among authors: hum dw. Biochim Biophys Acta. 2007 Aug;1771(8):1065-81. doi: 10.1016/j.bbalip.2007.02.003. Epub 2007 Feb 24. Biochim Biophys Acta. 2007. PMID: 17428730 Review.
Farnesoid X receptor represses hepatic lipase gene expression.
Sirvent A, Verhoeven AJ, Jansen H, Kosykh V, Darteil RJ, Hum DW, Fruchart JC, Staels B. Sirvent A, et al. Among authors: hum dw. J Lipid Res. 2004 Nov;45(11):2110-5. doi: 10.1194/jlr.M400221-JLR200. Epub 2004 Sep 1. J Lipid Res. 2004. PMID: 15342685 Free article.
The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.
Hanf R, Millatt LJ, Cariou B, Noel B, Rigou G, Delataille P, Daix V, Hum DW, Staels B. Hanf R, et al. Among authors: hum dw. Diab Vasc Dis Res. 2014 Nov;11(6):440-7. doi: 10.1177/1479164114548027. Epub 2014 Sep 11. Diab Vasc Dis Res. 2014. PMID: 25212694 Free article.
Factors to Consider in Development of Drugs for Pediatric Nonalcoholic Fatty Liver Disease.
Vos MB, Dimick-Santos L, Mehta R, Omokaro SO, Taminiau J, Schabel E, Kleiner DE, Szitanyi P, Socha P, Schwimmer JB, Noviello S, Silberg DG, Torstenson R, Miller V, Lavine JE; Liver Forum Pediatric Working Group. Vos MB, et al. Gastroenterology. 2019 Dec;157(6):1448-1456.e1. doi: 10.1053/j.gastro.2019.08.048. Epub 2019 Sep 12. Gastroenterology. 2019. PMID: 31520612 Free PMC article. No abstract available.
81 results