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Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.
Liu Y, Ferguson FM, Li L, Kuljanin M, Mills CE, Subramanian K, Harshbarger W, Gondi S, Wang J, Sorger PK, Mancias JD, Gray NS, Westover KD. Liu Y, et al. Among authors: mancias jd. Cell Chem Biol. 2020 Oct 15;27(10):1229-1240.e4. doi: 10.1016/j.chembiol.2020.07.011. Epub 2020 Aug 4. Cell Chem Biol. 2020. PMID: 32755567 Free PMC article.
Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nowak RP, DeAngelo SL, Buckley D, He Z, Donovan KA, An J, Safaee N, Jedrychowski MP, Ponthier CM, Ishoey M, Zhang T, Mancias JD, Gray NS, Bradner JE, Fischer ES. Nowak RP, et al. Among authors: mancias jd. Nat Chem Biol. 2018 Jul;14(7):706-714. doi: 10.1038/s41589-018-0055-y. Epub 2018 Jun 11. Nat Chem Biol. 2018. PMID: 29892083 Free PMC article.
Discovery of a selective inhibitor of doublecortin like kinase 1.
Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, Koren J, Dieguez-Martinez N, Espinosa S, Zeng Z, Corona CR, Vasta JD, Ohi R, Sim T, Kim ND, Harshbarger W, Lizcano JM, Robers MB, Muthaswamy S, Lin CY, Look AT, Haigis KM, Mancias JD, Wolpin BM, Aguirre AJ, Hahn WC, Westover KD, Gray NS. Ferguson FM, et al. Among authors: mancias jd. Nat Chem Biol. 2020 Jun;16(6):635-643. doi: 10.1038/s41589-020-0506-0. Epub 2020 Apr 6. Nat Chem Biol. 2020. PMID: 32251410 Free PMC article.
Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules.
Nabet B, Ferguson FM, Seong BKA, Kuljanin M, Leggett AL, Mohardt ML, Robichaud A, Conway AS, Buckley DL, Mancias JD, Bradner JE, Stegmaier K, Gray NS. Nabet B, et al. Among authors: mancias jd. Nat Commun. 2020 Sep 18;11(1):4687. doi: 10.1038/s41467-020-18377-w. Nat Commun. 2020. PMID: 32948771 Free PMC article.
Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer.
Banh RS, Biancur DE, Yamamoto K, Sohn ASW, Walters B, Kuljanin M, Gikandi A, Wang H, Mancias JD, Schneider RJ, Pacold ME, Kimmelman AC. Banh RS, et al. Among authors: mancias jd. Cell. 2020 Nov 25;183(5):1202-1218.e25. doi: 10.1016/j.cell.2020.10.016. Epub 2020 Nov 2. Cell. 2020. PMID: 33142117 Free PMC article.
Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer.
Malone CF, Dharia NV, Kugener G, Forman AB, Rothberg MV, Abdusamad M, Gonzalez A, Kuljanin M, Robichaud AL, Conway AS, Dempster JM, Paolella BR, Dumont N, Hovestadt V, Mancias JD, Younger ST, Root DE, Golub TR, Vazquez F, Stegmaier K. Malone CF, et al. Among authors: mancias jd. Cancer Discov. 2021 Sep;11(9):2282-2299. doi: 10.1158/2159-8290.CD-20-1213. Epub 2021 Apr 21. Cancer Discov. 2021. PMID: 33883167 Free PMC article.
An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML.
Lin S, Larrue C, Scheidegger NK, Seong BKA, Dharia NV, Kuljanin M, Wechsler CS, Kugener G, Robichaud AL, Conway AS, Mashaka T, Mouche S, Adane B, Ryan JA, Mancias JD, Younger ST, Piccioni F, Lee LH, Wunderlich M, Letai A, Tamburini J, Stegmaier K. Lin S, et al. Among authors: mancias jd. Cancer Discov. 2022 Feb;12(2):432-449. doi: 10.1158/2159-8290.CD-20-1851. Epub 2021 Sep 16. Cancer Discov. 2022. PMID: 34531254 Free PMC article.
Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function.
Zmyslowska A, Kuljanin M, Malachowska B, Stanczak M, Michalek D, Wlodarczyk A, Grot D, Taha J, Pawlik B, Lebiedzińska-Arciszewska M, Nieznanska H, Wieckowski MR, Rieske P, Mancias JD, Borowiec M, Mlynarski W, Fendler W. Zmyslowska A, et al. Among authors: mancias jd. Cell Commun Signal. 2021 Nov 20;19(1):116. doi: 10.1186/s12964-021-00791-2. Cell Commun Signal. 2021. PMID: 34801048 Free PMC article.
69 results