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Erythropoietin receptor in B cells plays a role in bone remodeling in mice.
Deshet-Unger N, Kolomansky A, Ben-Califa N, Hiram-Bab S, Gilboa D, Liron T, Ibrahim M, Awida Z, Gorodov A, Oster HS, Mittelman M, Rauner M, Wielockx B, Gabet Y, Neumann D. Deshet-Unger N, et al. Among authors: mittelman m. Theranostics. 2020 Jul 9;10(19):8744-8756. doi: 10.7150/thno.45845. eCollection 2020. Theranostics. 2020. PMID: 32754275 Free PMC article.
Erythropoietin has an anti-myeloma effect - a hypothesis based on a clinical observation supported by animal studies.
Mittelman M, Zeidman A, Kanter P, Katz O, Oster H, Rund D, Neumann D. Mittelman M, et al. Eur J Haematol. 2004 Mar;72(3):155-65. doi: 10.1046/j.0902-4441.2003.00190.x. Eur J Haematol. 2004. PMID: 14962233
We proceeded and tested that hypothesis in mouse models of myeloma (Mittelman M et al., Proc Natl Acad Sci USA 98:5181,2001). In these models we confirmed that rHuEpo induced tumor regression in about 50% of the BALB/c mice inoculated with MOPC-315 myeloma cells. .. …
We proceeded and tested that hypothesis in mouse models of myeloma (Mittelman M et al., Proc Natl Acad Sci USA 98:5181,2001). …
Erythropoietin enhances immune responses in mice.
Katz O, Gil L, Lifshitz L, Prutchi-Sagiv S, Gassmann M, Mittelman M, Neumann D. Katz O, et al. Among authors: mittelman m. Eur J Immunol. 2007 Jun;37(6):1584-93. doi: 10.1002/eji.200637025. Eur J Immunol. 2007. PMID: 17458859 Free article.
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