Ince I - Search Results

1

Integration of physiological changes during the postpartum period into a PBPK framework and prediction of amoxicillin disposition before and shortly after delivery.

Dallmann A, Himstedt A, Solodenko J, Ince I, Hempel G, Eissing T. Dallmann A, et al. Among authors: ince i. J Pharmacokinet Pharmacodyn. 2020 Aug;47(4):341-359. doi: 10.1007/s10928-020-09706-z. Epub 2020 Aug 3. J Pharmacokinet Pharmacodyn. 2020. PMID: 32748112

2

Physiologically Based Pharmacokinetic Modeling of Renally Cleared Drugs in Pregnant Women.

Dallmann A, Ince I, Solodenko J, Meyer M, Willmann S, Eissing T, Hempel G. Dallmann A, et al. Among authors: ince i. Clin Pharmacokinet. 2017 Dec;56(12):1525-1541. doi: 10.1007/s40262-017-0538-0. Clin Pharmacokinet. 2017. PMID: 28391404

3

Gestation-Specific Changes in the Anatomy and Physiology of Healthy Pregnant Women: An Extended Repository of Model Parameters for Physiologically Based Pharmacokinetic Modeling in Pregnancy.

Dallmann A, Ince I, Meyer M, Willmann S, Eissing T, Hempel G. Dallmann A, et al. Among authors: ince i. Clin Pharmacokinet. 2017 Nov;56(11):1303-1330. doi: 10.1007/s40262-017-0539-z. Clin Pharmacokinet. 2017. PMID: 28401479 Review.

4

A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.

Dallmann A, Ince I, Coboeken K, Eissing T, Hempel G. Dallmann A, et al. Among authors: ince i. Clin Pharmacokinet. 2018 Jun;57(6):749-768. doi: 10.1007/s40262-017-0594-5. Clin Pharmacokinet. 2018. PMID: 28924743

5

Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant Women.

Dallmann A, Solodenko J, Ince I, Eissing T. Dallmann A, et al. Among authors: ince i. CPT Pharmacometrics Syst Pharmacol. 2018 Jul;7(7):419-431. doi: 10.1002/psp4.12300. Epub 2018 Apr 20. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29569837 Free PMC article.

6

Predictive Pediatric Modeling and Simulation Using Ontogeny Information.

Ince I, Solodenko J, Frechen S, Dallmann A, Niederalt C, Schlender J, Burghaus R, Lippert J, Willmann S. Ince I, et al. J Clin Pharmacol. 2019 Sep;59 Suppl 1:S95-S103. doi: 10.1002/jcph.1497. J Clin Pharmacol. 2019. PMID: 31502689 Review.

7

A generic framework for the physiologically-based pharmacokinetic platform qualification of PK-Sim and its application to predicting cytochrome P450 3A4-mediated drug-drug interactions.

Frechen S, Solodenko J, Wendl T, Dallmann A, Ince I, Lehr T, Lippert J, Burghaus R. Frechen S, et al. Among authors: ince i. CPT Pharmacometrics Syst Pharmacol. 2021 Jun;10(6):633-644. doi: 10.1002/psp4.12636. Epub 2021 May 24. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33946131 Free PMC article.

8

Predictive Performance of Physiology-Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small-Molecule Compounds in Children.

Ince I, Dallmann A, Frechen S, Coboeken K, Niederalt C, Wendl T, Block M, Meyer M, Eissing T, Burghaus R, Lippert J, Willmann S, Schlender JF. Ince I, et al. J Clin Pharmacol. 2021 Jun;61 Suppl 1(Suppl 1):S70-S82. doi: 10.1002/jcph.1869. J Clin Pharmacol. 2021. PMID: 34185905 Free PMC article.

9

Applied physiologically-based pharmacokinetic modeling to assess uridine diphosphate-glucuronosyltransferase-mediated drug-drug interactions for Vericiguat.

Frechen S, Ince I, Dallmann A, Gerisch M, Jungmann NA, Becker C, Lobmeyer M, Trujillo ME, Xu S, Burghaus R, Meyer M. Frechen S, et al. Among authors: ince i. CPT Pharmacometrics Syst Pharmacol. 2024 Jan;13(1):79-92. doi: 10.1002/psp4.13059. Epub 2023 Oct 12. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 37794724 Free PMC article.

10

Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically-based pharmacokinetic predictions.

Willmann S, Coboeken K, Zhang Y, Mayer H, Ince I, Mesic E, Thelen K, Kubitza D, Lensing AWA, Yang H, Zhu P, Mück W, Drenth HJ, Lippert J. Willmann S, et al. Among authors: ince i. CPT Pharmacometrics Syst Pharmacol. 2021 Oct;10(10):1195-1207. doi: 10.1002/psp4.12688. Epub 2021 Aug 23. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34292671 Free PMC article.

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