Intracellular alkalinization by phosphate uptake via type III sodium-phosphate cotransporter participates in high-phosphate-induced mitochondrial oxidative stress and defective insulin secretion.
Nguyen TT, Quan X, Xu S, Das R, Cha SK, Kong ID, Shong M, Wollheim CB, Park KS.
Nguyen TT, et al. Among authors: das r.
FASEB J. 2016 Dec;30(12):3979-3988. doi: 10.1096/fj.201600455RR. Epub 2016 Aug 26.
FASEB J. 2016.
PMID: 27565711
We propose that P(i) transport across the plasma membrane and consequent cytosolic alkalinization could be a therapeutic target for protection from P(i) toxicity in insulin-secreting cells, as well as in other cell types.-Nguyen, T. T., Quan, X., Xu, S., Das, R., Ch …
We propose that P(i) transport across the plasma membrane and consequent cytosolic alkalinization could be a therapeutic target for protecti …