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Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.
Syed F, Tersey SA, Turatsinze JV, Felton JL, Kang NJ, Nelson JB, Sims EK, Defrance M, Bizet M, Fuks F, Cnop M, Bugliani M, Marchetti P, Ziegler AG, Bonifacio E, Webb-Robertson BJ, Balamurugan AN, Evans-Molina C, Eizirik DL, Mather KJ, Arslanian S, Mirmira RG. Syed F, et al. Among authors: mather kj. Clin Epigenetics. 2020 Jul 31;12(1):116. doi: 10.1186/s13148-020-00906-5. Clin Epigenetics. 2020. PMID: 32736653 Free PMC article.
Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium.
Hannon TS, Kahn SE, Utzschneider KM, Buchanan TA, Nadeau KJ, Zeitler PS, Ehrmann DA, Arslanian SA, Caprio S, Edelstein SL, Savage PJ, Mather KJ; RISE Consortium. Hannon TS, et al. Among authors: mather kj. Diabetes Obes Metab. 2018 Jan;20(1):14-24. doi: 10.1111/dom.13005. Epub 2017 Jun 22. Diabetes Obes Metab. 2018. PMID: 28493515 Free PMC article. Review.
β-cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults.
Utzschneider KM, Tripputi MT, Kozedub A, Mather KJ, Nadeau KJ, Edelstein SL, Hannon TS, Arslanian SA, Cree-Green M, Buchanan TA, Caprio S, Mari A; RISE Consortium. Utzschneider KM, et al. Among authors: mather kj. Pediatr Diabetes. 2020 Dec;21(8):1421-1429. doi: 10.1111/pedi.13113. Epub 2020 Oct 14. Pediatr Diabetes. 2020. PMID: 32902875 Free PMC article.
Withdrawal of medications leads to worsening of OGTT parameters in youth with impaired glucose tolerance or recently-diagnosed type 2 diabetes.
Hannon TS, Edelstein SL, Arslanian SA, Caprio S, Zeitler PS, Buchanan TA, Ehrmann DA, Mather KJ, Tripputi M, Kahn SE, Nadeau KJ; RISE Consortium. Hannon TS, et al. Among authors: mather kj. Pediatr Diabetes. 2020 Dec;21(8):1437-1446. doi: 10.1111/pedi.13129. Epub 2020 Oct 13. Pediatr Diabetes. 2020. PMID: 32985775 Free PMC article. Clinical Trial.
222 results