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Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease.
Simard JC, Thibodeau JF, Leduc M, Tremblay M, Laverdure A, Sarra-Bournet F, Gagnon W, Ouboudinar J, Gervais L, Felton A, Letourneau S, Geerts L, Cloutier MP, Hince K, Corpuz R, Blais A, Quintela VM, Duceppe JS, Abbott SD, Blais A, Zacharie B, Laurin P, Laplante SR, Kennedy CRJ, Hébert RL, Leblond FA, Grouix B, Gagnon L. Simard JC, et al. Among authors: leblond fa. Sci Rep. 2020 Jul 29;10(1):12778. doi: 10.1038/s41598-020-69675-8. Sci Rep. 2020. PMID: 32728158 Free PMC article.
A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84.
Gagnon L, Leduc M, Thibodeau JF, Zhang MZ, Grouix B, Sarra-Bournet F, Gagnon W, Hince K, Tremblay M, Geerts L, Kennedy CRJ, Hébert RL, Gutsol A, Holterman CE, Kamto E, Gervais L, Ouboudinar J, Richard J, Felton A, Laverdure A, Simard JC, Létourneau S, Cloutier MP, Leblond FA, Abbott SD, Penney C, Duceppe JS, Zacharie B, Dupuis J, Calderone A, Nguyen QT, Harris RC, Laurin P. Gagnon L, et al. Among authors: leblond fa. Am J Pathol. 2018 May;188(5):1132-1148. doi: 10.1016/j.ajpath.2018.01.009. Epub 2018 Feb 16. Am J Pathol. 2018. PMID: 29454750 Free article.
PBI-4050 via GPR40 activation improves adenine-induced kidney injury in mice.
Thibodeau JF, Simard JC, Holterman CE, Blais A, Cloutier MP, Medeiros T, Leduc M, Grouix B, Leblond FA, Burger D, Hébert RL, Kennedy CRJ, Gagnon L. Thibodeau JF, et al. Among authors: leblond fa. Clin Sci (Lond). 2019 Jul 22;133(14):1587-1602. doi: 10.1042/CS20190479. Print 2019 Jul 31. Clin Sci (Lond). 2019. PMID: 31308217
PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway.
Grouix B, Sarra-Bournet F, Leduc M, Simard JC, Hince K, Geerts L, Blais A, Gervais L, Laverdure A, Felton A, Richard J, Ouboudinar J, Gagnon W, Leblond FA, Laurin P, Gagnon L. Grouix B, et al. Among authors: leblond fa. J Pharmacol Exp Ther. 2018 Oct;367(1):71-81. doi: 10.1124/jpet.118.250068. Epub 2018 Aug 9. J Pharmacol Exp Ther. 2018. PMID: 30093459
Drug metabolism in chronic renal failure.
Pichette V, Leblond FA. Pichette V, et al. Among authors: leblond fa. Curr Drug Metab. 2003 Apr;4(2):91-103. doi: 10.2174/1389200033489532. Curr Drug Metab. 2003. PMID: 12678690 Review.
Effect of hemodialysis on hepatic cytochrome P450 functional expression.
Michaud J, Nolin TD, Naud J, Dani M, Lafrance JP, Leblond FA, Himmelfarb J, Pichette V. Michaud J, et al. Among authors: leblond fa. J Pharmacol Sci. 2008 Oct;108(2):157-63. doi: 10.1254/jphs.08042fp. Epub 2008 Oct 9. J Pharmacol Sci. 2008. PMID: 18845914 Free article.
ESRD impairs nonrenal clearance of fexofenadine but not midazolam.
Nolin TD, Frye RF, Le P, Sadr H, Naud J, Leblond FA, Pichette V, Himmelfarb J. Nolin TD, et al. Among authors: leblond fa. J Am Soc Nephrol. 2009 Oct;20(10):2269-76. doi: 10.1681/ASN.2009010082. Epub 2009 Aug 20. J Am Soc Nephrol. 2009. PMID: 19696225 Free PMC article.
76 results