Laplante SR - Search Results

1

Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease.

Simard JC, Thibodeau JF, Leduc M, Tremblay M, Laverdure A, Sarra-Bournet F, Gagnon W, Ouboudinar J, Gervais L, Felton A, Letourneau S, Geerts L, Cloutier MP, Hince K, Corpuz R, Blais A, Quintela VM, Duceppe JS, Abbott SD, Blais A, Zacharie B, Laurin P, Laplante SR, Kennedy CRJ, Hébert RL, Leblond FA, Grouix B, Gagnon L. Simard JC, et al. Among authors: laplante sr. Sci Rep. 2020 Jul 29;10(1):12778. doi: 10.1038/s41598-020-69675-8. Sci Rep. 2020. PMID: 32728158 Free PMC article.

2

Computational design of candidate multi-epitope vaccine against SARS-CoV-2 targeting structural (S and N) and non-structural (NSP3 and NSP12) proteins.

Ali Z, Cardoza JV, Basak S, Narsaria U, Singh VP, Isaac SP, França TCC, LaPlante SR, George SS. Ali Z, et al. Among authors: laplante sr. J Biomol Struct Dyn. 2023;41(22):13348-13367. doi: 10.1080/07391102.2023.2173297. Epub 2023 Feb 6. J Biomol Struct Dyn. 2023. PMID: 36744449

3

Dimethylthiazolidine carboxylic acid as a rigid p3 unit in inhibitors of serine proteases: application to two targets.

Kawai SH, Aubry N, Duceppe JS, Llinàs-Brunet M, LaPlante SR. Kawai SH, et al. Among authors: laplante sr. Chem Biol Drug Des. 2009 Nov;74(5):517-22. doi: 10.1111/j.1747-0285.2009.00870.x. Epub 2009 Sep 22. Chem Biol Drug Des. 2009. PMID: 19780760

4

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.

Beaulieu PL, Gillard J, Bykowski D, Brochu C, Dansereau N, Duceppe JS, Haché B, Jakalian A, Lagacé L, LaPlante S, McKercher G, Moreau E, Perreault S, Stammers T, Thauvette L, Warrington J, Kukolj G. Beaulieu PL, et al. Bioorg Med Chem Lett. 2006 Oct 1;16(19):4987-93. doi: 10.1016/j.bmcl.2006.07.074. Bioorg Med Chem Lett. 2006. PMID: 16908138

5

NMR strategies to support medicinal chemistry workflows for primary structure determination.

Oguadinma P, Bilodeau F, LaPlante SR. Oguadinma P, et al. Among authors: laplante sr. Bioorg Med Chem Lett. 2017 Jan 15;27(2):242-247. doi: 10.1016/j.bmcl.2016.11.066. Epub 2016 Nov 24. Bioorg Med Chem Lett. 2017. PMID: 27913183

6

Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases.

Ayotte Y, Bernet E, Bilodeau F, Cimino M, Gagnon D, Lebughe M, Mistretta M, Ogadinma P, Ouali SL, Sow AA, Chatel-Chaix L, Descoteaux A, Manina G, Richard D, Veyrier F, LaPlante SR. Ayotte Y, et al. Among authors: laplante sr. ACS Chem Biol. 2021 Nov 19;16(11):2158-2163. doi: 10.1021/acschembio.1c00657. Epub 2021 Oct 26. ACS Chem Biol. 2021. PMID: 34699722

7

Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay.

Ayotte Y, Marando VM, Vaillancourt L, Bouchard P, Heffron G, Coote PW, Larda ST, LaPlante SR. Ayotte Y, et al. Among authors: laplante sr. J Med Chem. 2019 Sep 12;62(17):7885-7896. doi: 10.1021/acs.jmedchem.9b00653. Epub 2019 Sep 3. J Med Chem. 2019. PMID: 31422659

8

The critical C-terminus of the small subunit of herpes simplex virus ribonucleotide reductase is mobile and conformationally similar to C-terminal peptides.

Laplante SR, Aubry N, Liuzzi M, Thelander L, Ingemarson R, Moss N. Laplante SR, et al. Int J Pept Protein Res. 1994 Dec;44(6):549-55. doi: 10.1111/j.1399-3011.1994.tb01143.x. Int J Pept Protein Res. 1994. PMID: 7705976

9

Several polyhydroxymonoamide renin inhibitors assume similar conformations in the unbound and renin-bound states.

Laplante SR, Tong L, Aubry N, Pav S, Jung G, Anderson PC. Laplante SR, et al. Int J Pept Protein Res. 1996 Nov;48(5):401-10. doi: 10.1111/j.1399-3011.1996.tb00858.x. Int J Pept Protein Res. 1996. PMID: 8956073

10

Evidence of a conformational change in the human cytomegalovirus protease upon binding of peptidyl-activated carbonyl inhibitors.

Bonneau PR, Grand-Maître C, Greenwood DJ, Lagacé L, LaPlante SR, Massariol MJ, Ogilvie WW, O'Meara JA, Kawai SH. Bonneau PR, et al. Among authors: laplante sr. Biochemistry. 1997 Oct 14;36(41):12644-52. doi: 10.1021/bi970366x. Biochemistry. 1997. PMID: 9376371

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