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Insulin signaling requires glucose to promote lipid anabolism in adipocytes.
Krycer JR, Quek LE, Francis D, Zadoorian A, Weiss FC, Cooke KC, Nelson ME, Diaz-Vegas A, Humphrey SJ, Scalzo R, Hirayama A, Ikeda S, Shoji F, Suzuki K, Huynh K, Giles C, Varney B, Nagarajan SR, Hoy AJ, Soga T, Meikle PJ, Cooney GJ, Fazakerley DJ, James DE. Krycer JR, et al. Among authors: hoy aj. J Biol Chem. 2020 Sep 18;295(38):13250-13266. doi: 10.1074/jbc.RA120.014907. Epub 2020 Jul 28. J Biol Chem. 2020. PMID: 32723868 Free PMC article.
Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation.
Hoy AJ, Bruce CR, Cederberg A, Turner N, James DE, Cooney GJ, Kraegen EW. Hoy AJ, et al. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1358-64. doi: 10.1152/ajpendo.00133.2007. Epub 2007 Sep 4. Am J Physiol Endocrinol Metab. 2007. PMID: 17785505 Free article.
Hyperglycemia also causes insulin resistance, and our group (Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB. Am J Physiol Endocrinol Metab Endocrinol Metab 290: E471-E479, 2006) has recently demonstrated that hyperglycemia generated by gluco …
Hyperglycemia also causes insulin resistance, and our group (Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruder …
Insulin resistance is a cellular antioxidant defense mechanism.
Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE. Hoehn KL, et al. Among authors: hoy aj. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. doi: 10.1073/pnas.0902380106. Epub 2009 Sep 30. Proc Natl Acad Sci U S A. 2009. PMID: 19805130 Free PMC article.
Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity.
Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE, Cooney GJ. Hoehn KL, et al. Among authors: hoy aj. Cell Metab. 2010 Jan;11(1):70-6. doi: 10.1016/j.cmet.2009.11.008. Cell Metab. 2010. PMID: 20074529 Free PMC article.
Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1β involves reductions in long-chain acyl-CoA levels and oxidative stress.
Wright LE, Brandon AE, Hoy AJ, Forsberg GB, Lelliott CJ, Reznick J, Löfgren L, Oscarsson J, Strömstedt M, Cooney GJ, Turner N. Wright LE, et al. Among authors: hoy aj. Diabetologia. 2011 Jun;54(6):1417-26. doi: 10.1007/s00125-011-2068-x. Epub 2011 Feb 18. Diabetologia. 2011. PMID: 21331471
The evolution of insulin resistance in muscle of the glucose infused rat.
Brandon AE, Hoy AJ, Wright LE, Turner N, Hegarty BD, Iseli TJ, Julia Xu X, Cooney GJ, Saha AK, Ruderman NB, Kraegen EW. Brandon AE, et al. Among authors: hoy aj. Arch Biochem Biophys. 2011 May 15;509(2):133-41. doi: 10.1016/j.abb.2011.03.008. Epub 2011 Mar 21. Arch Biochem Biophys. 2011. PMID: 21420928 Free PMC article.
69 results