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Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study.
de la Rubia JE, Drehmer E, Platero JL, Benlloch M, Caplliure-Llopis J, Villaron-Casales C, de Bernardo N, AlarcÓn J, Fuente C, Carrera S, Sancho D, GarcÍa-Pardo P, Pascual R, JuÁrez M, Cuerda-Ballester M, Forner A, Sancho-Castillo S, Barrios C, Obrador E, Marchio P, Salvador R, Holmes HE, Dellinger RW, Guarente L, Estrela JM. de la Rubia JE, et al. Among authors: holmes he. Amyotroph Lateral Scler Frontotemporal Degener. 2019 Feb;20(1-2):115-122. doi: 10.1080/21678421.2018.1536152. Epub 2019 Jan 22. Amyotroph Lateral Scler Frontotemporal Degener. 2019. PMID: 30668199 Clinical Trial.
Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.
Clayton EL, Mancuso R, Nielsen TT, Mizielinska S, Holmes H, Powell N, Norona F, Larsen JO, Milioto C, Wilson KM, Lythgoe MF, Ourselin S, Nielsen JE, Johannsen P, Holm I, Collinge J; FReJA; Oliver PL, Gomez-Nicola D, Isaacs AM. Clayton EL, et al. Hum Mol Genet. 2017 Mar 1;26(5):873-887. doi: 10.1093/hmg/ddx003. Hum Mol Genet. 2017. PMID: 28093491 Free PMC article.
In vivo imaging of tau pathology using multi-parametric quantitative MRI.
Wells JA, O'Callaghan JM, Holmes HE, Powell NM, Johnson RA, Siow B, Torrealdea F, Ismail O, Walker-Samuel S, Golay X, Rega M, Richardson S, Modat M, Cardoso MJ, Ourselin S, Schwarz AJ, Ahmed Z, Murray TK, O'Neill MJ, Collins EC, Colgan N, Lythgoe MF. Wells JA, et al. Among authors: holmes he. Neuroimage. 2015 May 1;111:369-78. doi: 10.1016/j.neuroimage.2015.02.023. Epub 2015 Feb 17. Neuroimage. 2015. PMID: 25700953 Free PMC article.
Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease.
O'Callaghan J, Holmes H, Powell N, Wells JA, Ismail O, Harrison IF, Siow B, Johnson R, Ahmed Z, Fisher A, Meftah S, O'Neill MJ, Murray TK, Collins EC, Shmueli K, Lythgoe MF. O'Callaghan J, et al. Neuroimage. 2017 Oct 1;159:334-345. doi: 10.1016/j.neuroimage.2017.08.003. Epub 2017 Aug 4. Neuroimage. 2017. PMID: 28797738 Free PMC article.
Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer's disease.
Wells JA, Holmes HE, O'Callaghan JM, Colgan N, Ismail O, Fisher EM, Siow B, Murray TK, Schwarz AJ, O'Neill MJ, Collins EC, Lythgoe MF. Wells JA, et al. Among authors: holmes he. J Cereb Blood Flow Metab. 2015 Mar;35(3):359-62. doi: 10.1038/jcbfm.2014.224. Epub 2014 Dec 17. J Cereb Blood Flow Metab. 2015. PMID: 25515210 Free PMC article.
Imaging the accumulation and suppression of tau pathology using multiparametric MRI.
Holmes HE, Colgan N, Ismail O, Ma D, Powell NM, O'Callaghan JM, Harrison IF, Johnson RA, Murray TK, Ahmed Z, Heggenes M, Fisher A, Cardoso MJ, Modat M, Walker-Samuel S, Fisher EM, Ourselin S, O'Neill MJ, Wells JA, Collins EC, Lythgoe MF. Holmes HE, et al. Neurobiol Aging. 2016 Mar;39:184-94. doi: 10.1016/j.neurobiolaging.2015.12.001. Epub 2015 Dec 15. Neurobiol Aging. 2016. PMID: 26923415 Free PMC article.
26 results