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Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients.
Int J Mol Sci. 2020 Jul 22;21(15):5188. doi: 10.3390/ijms21155188.
Int J Mol Sci. 2020.
PMID: 32707880
Free PMC article.
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Ullman JC, Arguello A, Getz JA, Bhalla A, Mahon CS, Wang J, Giese T, Bedard C, Kim DJ, Blumenfeld JR, Liang N, Ravi R, Nugent AA, Davis SS, Ha C, Duque J, Tran HL, Wells RC, Lianoglou S, Daryani VM, Kwan W, Solanoy H, Nguyen H, Earr T, Dugas JC, Tuck MD, Harvey JL, Reyzer ML, Caprioli RM, Hall S, Poda S, Sanchez PE, Dennis MS, Gunasekaran K, Srivastava A, Sandmann T, Henne KR, Thorne RG, Di Paolo G, Astarita G, Diaz D, Silverman AP, Watts RJ, Sweeney ZK, Kariolis MS, Henry AG.
Ullman JC, et al. Among authors: blumenfeld jr.
Sci Transl Med. 2020 May 27;12(545):eaay1163. doi: 10.1126/scitranslmed.aay1163.
Sci Transl Med. 2020.
PMID: 32461331
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Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits.
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Grone B, Zilberter M, Yip O, Rao A, Nelson MR, Hao Y, Thomas R, Yoon SY, Arriola P, Huang Y.
Koutsodendris N, et al.
Nat Aging. 2023 Mar;3(3):275-296. doi: 10.1038/s43587-023-00368-3. Epub 2023 Feb 20.
Nat Aging. 2023.
PMID: 37118426
Free PMC article.
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APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release.
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Yip O, Rao A, Kim MJ, Nelson MR, Wang YH, Grone B, Hao Y, Thomas R, Zilberter M, Yoon SY, Arriola P, Huang Y.
Koutsodendris N, et al.
Cell Rep. 2023 Oct 31;42(10):113252. doi: 10.1016/j.celrep.2023.113252. Epub 2023 Oct 19.
Cell Rep. 2023.
PMID: 37863057
Free PMC article.
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Cell type-specific roles of APOE4 in Alzheimer disease.
Blumenfeld J, Yip O, Kim MJ, Huang Y.
Blumenfeld J, et al.
Nat Rev Neurosci. 2024 Feb;25(2):91-110. doi: 10.1038/s41583-023-00776-9. Epub 2024 Jan 8.
Nat Rev Neurosci. 2024.
PMID: 38191720
Free PMC article.
Review.
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Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model.
Rao A, Chen N, Kim MJ, Blumenfeld J, Yip O, Hao Y, Liang Z, Nelson MR, Koutsodendris N, Grone B, Ding L, Yoon SY, Arriola P, Huang Y.
Rao A, et al.
bioRxiv [Preprint]. 2023 Nov 14:2023.11.10.566510. doi: 10.1101/2023.11.10.566510.
bioRxiv. 2023.
PMID: 38014339
Free PMC article.
Preprint.
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The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.
Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J, Traglia M, Kim MJ, Koutsodendris N, Rao A, Grone B, Hao Y, Yoon SY, Xu Q, De Leon S, Choenyi T, Thomas R, Lopera F, Quiroz YT, Arboleda-Velasquez JF, Reiman EM, Mahley RW, Huang Y.
Nelson MR, et al.
Nat Neurosci. 2023 Dec;26(12):2104-2121. doi: 10.1038/s41593-023-01480-8. Epub 2023 Nov 13.
Nat Neurosci. 2023.
PMID: 37957317
Free PMC article.
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Are we making an impact on prostate cancer?
Figg WD, Blumenfeld JR.
Figg WD, et al. Among authors: blumenfeld jr.
Prostate Cancer Prostatic Dis. 1999 Mar;2(2):60-61. doi: 10.1038/sj.pcan.4500300.
Prostate Cancer Prostatic Dis. 1999.
PMID: 12496838
No abstract available.
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