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Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.
Laffranchi M, Elliston EL, Miranda E, Perez J, Ronzoni R, Jagger AM, Heyer-Chauhan N, Brantly ML, Fra A, Lomas DA, Irving JA. Laffranchi M, et al. Among authors: heyer chauhan n. JCI Insight. 2020 Jul 23;5(14):e135459. doi: 10.1172/jci.insight.135459. JCI Insight. 2020. PMID: 32699193 Free PMC article.
The structural basis for Z α1-antitrypsin polymerization in the liver.
Faull SV, Elliston ELK, Gooptu B, Jagger AM, Aldobiyan I, Redzej A, Badaoui M, Heyer-Chauhan N, Rashid ST, Reynolds GM, Adams DH, Miranda E, Orlova EV, Irving JA, Lomas DA. Faull SV, et al. Among authors: heyer chauhan n. Sci Adv. 2020 Oct 21;6(43):eabc1370. doi: 10.1126/sciadv.abc1370. Print 2020 Oct. Sci Adv. 2020. PMID: 33087346 Free PMC article.
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm.
Partridge FA, Forman R, Willis NJ, Bataille CJR, Murphy EA, Brown AE, Heyer-Chauhan N, Marinič B, Sowood DJC, Wynne GM, Else KJ, Russell AJ, Sattelle DB. Partridge FA, et al. Among authors: heyer chauhan n. PLoS Negl Trop Dis. 2018 Jul 11;12(7):e0006487. doi: 10.1371/journal.pntd.0006487. eCollection 2018 Jul. PLoS Negl Trop Dis. 2018. PMID: 29995893 Free PMC article.
Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo.
Partridge FA, Murphy EA, Willis NJ, Bataille CJ, Forman R, Heyer-Chauhan N, Marinič B, Sowood DJ, Wynne GM, Else KJ, Russell AJ, Sattelle DB. Partridge FA, et al. Among authors: heyer chauhan n. PLoS Negl Trop Dis. 2017 Feb 9;11(2):e0005359. doi: 10.1371/journal.pntd.0005359. eCollection 2017 Feb. PLoS Negl Trop Dis. 2017. PMID: 28182663 Free PMC article.
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.
Motamedi-Shad N, Jagger AM, Liedtke M, Faull SV, Nanda AS, Salvadori E, Wort JL, Kay CW, Heyer-Chauhan N, Miranda E, Perez J, Ordóñez A, Haq I, Irving JA, Lomas DA. Motamedi-Shad N, et al. Among authors: heyer chauhan n. Biochem J. 2016 Oct 1;473(19):3269-90. doi: 10.1042/BCJ20160159. Epub 2016 Jul 12. Biochem J. 2016. PMID: 27407165 Free PMC article.