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Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.
JCI Insight. 2020 Jul 23;5(14):e135459. doi: 10.1172/jci.insight.135459.
JCI Insight. 2020.
PMID: 32699193
Free PMC article.
The molecular species responsible for α1 -antitrypsin deficiency are suppressed by a small molecule chaperone.
Ronzoni R, Heyer-Chauhan N, Fra A, Pearce AC, Rüdiger M, Miranda E, Irving JA, Lomas DA.
Ronzoni R, et al. Among authors: heyer chauhan n.
FEBS J. 2021 Apr;288(7):2222-2237. doi: 10.1111/febs.15597. Epub 2020 Nov 11.
FEBS J. 2021.
PMID: 33058391
Free PMC article.
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The structural basis for Z α1-antitrypsin polymerization in the liver.
Faull SV, Elliston ELK, Gooptu B, Jagger AM, Aldobiyan I, Redzej A, Badaoui M, Heyer-Chauhan N, Rashid ST, Reynolds GM, Adams DH, Miranda E, Orlova EV, Irving JA, Lomas DA.
Faull SV, et al. Among authors: heyer chauhan n.
Sci Adv. 2020 Oct 21;6(43):eabc1370. doi: 10.1126/sciadv.abc1370. Print 2020 Oct.
Sci Adv. 2020.
PMID: 33087346
Free PMC article.
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2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm.
Partridge FA, Forman R, Willis NJ, Bataille CJR, Murphy EA, Brown AE, Heyer-Chauhan N, Marinič B, Sowood DJC, Wynne GM, Else KJ, Russell AJ, Sattelle DB.
Partridge FA, et al. Among authors: heyer chauhan n.
PLoS Negl Trop Dis. 2018 Jul 11;12(7):e0006487. doi: 10.1371/journal.pntd.0006487. eCollection 2018 Jul.
PLoS Negl Trop Dis. 2018.
PMID: 29995893
Free PMC article.
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Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo.
Partridge FA, Murphy EA, Willis NJ, Bataille CJ, Forman R, Heyer-Chauhan N, Marinič B, Sowood DJ, Wynne GM, Else KJ, Russell AJ, Sattelle DB.
Partridge FA, et al. Among authors: heyer chauhan n.
PLoS Negl Trop Dis. 2017 Feb 9;11(2):e0005359. doi: 10.1371/journal.pntd.0005359. eCollection 2017 Feb.
PLoS Negl Trop Dis. 2017.
PMID: 28182663
Free PMC article.
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An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.
Motamedi-Shad N, Jagger AM, Liedtke M, Faull SV, Nanda AS, Salvadori E, Wort JL, Kay CW, Heyer-Chauhan N, Miranda E, Perez J, Ordóñez A, Haq I, Irving JA, Lomas DA.
Motamedi-Shad N, et al. Among authors: heyer chauhan n.
Biochem J. 2016 Oct 1;473(19):3269-90. doi: 10.1042/BCJ20160159. Epub 2016 Jul 12.
Biochem J. 2016.
PMID: 27407165
Free PMC article.
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Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia.
Heyer-Chauhan N, Ovbude IJ, Hills AA, Sullivan MH, Hills FA.
Heyer-Chauhan N, et al.
J Perinat Med. 2014 May;42(3):329-38. doi: 10.1515/jpm-2013-0097.
J Perinat Med. 2014.
PMID: 24222257
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