Lum L - Search Results

1

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.

Koirala S, Klein J, Zheng Y, Glenn NO, Eisemann T, Fon Tacer K, Miller DJ, Kulak O, Lu M, Finkelstein DB, Neale G, Tillman H, Vogel P, Strand DW, Lum L, Brautigam CA, Pascal JM, Clements WK, Potts PR. Koirala S, et al. Among authors: lum l. Cell Rep. 2020 Jul 21;32(3):107922. doi: 10.1016/j.celrep.2020.107922. Cell Rep. 2020. PMID: 32698014 Free article.

2

A multiplexed luciferase-based screening platform for interrogating cancer-associated signal transduction in cultured cells.

Kulak O, Lum L. Kulak O, et al. Among authors: lum l. J Vis Exp. 2013 Jul 3;(77):e50369. doi: 10.3791/50369. J Vis Exp. 2013. PMID: 23852434 Free PMC article.

3

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.

Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, Otwinowski Z, Yamaguchi K, Garofalo LA, Ma Z, Wright W, Chen C, Shay JW, Zhang X, Lum L. Kulak O, et al. Among authors: lum l. Mol Cell Biol. 2015 Jul;35(14):2425-35. doi: 10.1128/MCB.00392-15. Epub 2015 May 4. Mol Cell Biol. 2015. PMID: 25939383 Free PMC article.

4

Regulation of tankyrase activity by a catalytic domain dimer interface.

Fan C, Yarravarapu N, Chen H, Kulak O, Dasari P, Herbert J, Yamaguchi K, Lum L, Zhang X. Fan C, et al. Among authors: lum l. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1780-1785. doi: 10.1016/j.bbrc.2018.07.113. Epub 2018 Jul 26. Biochem Biophys Res Commun. 2018. PMID: 30055800 Free PMC article.

5

Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts.

Kulak O, Yamaguchi K, Lum L. Kulak O, et al. Among authors: lum l. Methods Mol Biol. 2015;1263:3-14. doi: 10.1007/978-1-4939-2269-7_1. Methods Mol Biol. 2015. PMID: 25618332 Free PMC article.

6

A synthetic combinatorial approach to disabling deviant Hedgehog signaling.

Fan CW, Yarravarapu N, Shi H, Kulak O, Kim J, Chen C, Lum L. Fan CW, et al. Among authors: lum l. Sci Rep. 2018 Jan 18;8(1):1133. doi: 10.1038/s41598-018-19408-9. Sci Rep. 2018. PMID: 29348431 Free PMC article.

7

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

Jacob LS, Wu X, Dodge ME, Fan CW, Kulak O, Chen B, Tang W, Wang B, Amatruda JF, Lum L. Jacob LS, et al. Among authors: lum l. Sci Signal. 2011 Jan 25;4(157):ra4. doi: 10.1126/scisignal.2001225. Sci Signal. 2011. PMID: 21266715 Free PMC article.

8

Tankyrase is necessary for canonical Wnt signaling during kidney development.

Karner CM, Merkel CE, Dodge M, Ma Z, Lu J, Chen C, Lum L, Carroll TJ. Karner CM, et al. Among authors: lum l. Dev Dyn. 2010 Jul;239(7):2014-23. doi: 10.1002/dvdy.22340. Dev Dyn. 2010. PMID: 20549720 Free PMC article.

9

Structure-activity relationship studies of small-molecule inhibitors of Wnt response.

Lu J, Ma Z, Hsieh JC, Fan CW, Chen B, Longgood JC, Williams NS, Amatruda JF, Lum L, Chen C. Lu J, et al. Among authors: lum l. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3825-7. doi: 10.1016/j.bmcl.2009.04.040. Epub 2009 Apr 18. Bioorg Med Chem Lett. 2009. PMID: 19410457 Free PMC article.

10

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.

Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L. Dodge ME, et al. Among authors: lum l. J Biol Chem. 2012 Jun 29;287(27):23246-54. doi: 10.1074/jbc.M112.372029. Epub 2012 May 15. J Biol Chem. 2012. PMID: 22593577 Free PMC article.

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