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Selenium detoxification is required for cancer-cell survival.
Nat Metab. 2020 Jul;2(7):603-611. doi: 10.1038/s42255-020-0224-7. Epub 2020 Jul 6.
Nat Metab. 2020.
PMID: 32694795
Free PMC article.
Endogenous toxic metabolites and implications in cancer therapy.
Lee N, Spears ME, Carlisle AE, Kim D.
Lee N, et al. Among authors: spears me.
Oncogene. 2020 Aug;39(35):5709-5720. doi: 10.1038/s41388-020-01395-9. Epub 2020 Jul 24.
Oncogene. 2020.
PMID: 32709924
Free PMC article.
Review.
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xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers.
Lee N, Carlisle AE, Peppers A, Park SJ, Doshi MB, Spears ME, Kim D.
Lee N, et al. Among authors: spears me.
Antioxidants (Basel). 2021 Feb 20;10(2):317. doi: 10.3390/antiox10020317.
Antioxidants (Basel). 2021.
PMID: 33672555
Free PMC article.
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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells.
Spears ME, Lee N, Hwang S, Park SJ, Carlisle AE, Li R, Doshi MB, Armando AM, Gao J, Simin K, Zhu LJ, Greer PL, Quehenberger O, Torres EM, Kim D.
Spears ME, et al.
Cell Rep. 2022 Sep 27;40(13):111415. doi: 10.1016/j.celrep.2022.111415.
Cell Rep. 2022.
PMID: 36170811
Free PMC article.
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Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells.
Doshi MB, Lee N, Tseyang T, Ponomarova O, Goel HL, Spears M, Li R, Zhu LJ, Ashwood C, Simin K, Jang C, Mercurio AM, Walhout AJM, Spinelli JB, Kim D.
Doshi MB, et al.
Nature. 2023 Nov;623(7987):625-632. doi: 10.1038/s41586-023-06676-3. Epub 2023 Oct 25.
Nature. 2023.
PMID: 37880368
Free PMC article.
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