Schiedel M - Search Results

1

HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)*.

Schiedel M, Lehotzky A, Szunyogh S, Oláh J, Hammelmann S, Wössner N, Robaa D, Einsle O, Sippl W, Ovádi J, Jung M. Schiedel M, et al. Chembiochem. 2020 Dec 1;21(23):3371-3376. doi: 10.1002/cbic.202000351. Epub 2020 Aug 27. Chembiochem. 2020. PMID: 32672888 Free PMC article.

2

Back in Person: Frontiers in Medicinal Chemistry 2023.

Gehringer M, Pape F, Méndez M, Barbie P, Unzue Lopez A, Lefranc J, Klingler FM, Hessler G, Langer T, Diamanti E, Schiedel M. Gehringer M, et al. Among authors: schiedel m. ChemMedChem. 2023 Oct 4;18(19):e202300344. doi: 10.1002/cmdc.202300344. Epub 2023 Jul 24. ChemMedChem. 2023. PMID: 37485831

3

[Dysregulation of histone acetylation as a molecular basis for the development of dementia].

Schiedel M, Jung M. Schiedel M, et al. Pharm Unserer Zeit. 2011 Jul;40(4):297-9. doi: 10.1002/pauz.201190039. Pharm Unserer Zeit. 2011. PMID: 21698626 German. No abstract available.

4

Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni.

Schiedel M, Marek M, Lancelot J, Karaman B, Almlöf I, Schultz J, Sippl W, Pierce RJ, Romier C, Jung M. Schiedel M, et al. J Biomol Screen. 2015 Jan;20(1):112-21. doi: 10.1177/1087057114555307. Epub 2014 Oct 16. J Biomol Screen. 2015. PMID: 25325257

5

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M. Rumpf T, et al. Among authors: schiedel m. Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263. Nat Commun. 2015. PMID: 25672491 Free PMC article.

6

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.

Schiedel M, Rumpf T, Karaman B, Lehotzky A, Oláh J, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M. Schiedel M, et al. J Med Chem. 2016 Feb 25;59(4):1599-612. doi: 10.1021/acs.jmedchem.5b01517. Epub 2016 Jan 7. J Med Chem. 2016. PMID: 26696402 Free article.

7

Structure-Based Development of an Affinity Probe for Sirtuin 2.

Schiedel M, Rumpf T, Karaman B, Lehotzky A, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6. doi: 10.1002/anie.201509843. Epub 2016 Jan 8. Angew Chem Int Ed Engl. 2016. PMID: 26748890

8

A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation.

Galleano I, Schiedel M, Jung M, Madsen AS, Olsen CA. Galleano I, et al. Among authors: schiedel m. J Med Chem. 2016 Feb 11;59(3):1021-31. doi: 10.1021/acs.jmedchem.5b01532. Epub 2016 Jan 20. J Med Chem. 2016. PMID: 26788965

9

The Current State of NAD⁺ -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.

Schiedel M, Robaa D, Rumpf T, Sippl W, Jung M. Schiedel M, et al. Med Res Rev. 2018 Jan;38(1):147-200. doi: 10.1002/med.21436. Epub 2017 Jan 17. Med Res Rev. 2018. PMID: 28094444 Review.

10

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).

Schiedel M, Herp D, Hammelmann S, Swyter S, Lehotzky A, Robaa D, Oláh J, Ovádi J, Sippl W, Jung M. Schiedel M, et al. J Med Chem. 2018 Jan 25;61(2):482-491. doi: 10.1021/acs.jmedchem.6b01872. Epub 2017 Apr 17. J Med Chem. 2018. PMID: 28379698

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