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Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Palikuqi B, Nguyen DT, Li G, Schreiner R, Pellegata AF, Liu Y, Redmond D, Geng F, Lin Y, Gómez-Salinero JM, Yokoyama M, Zumbo P, Zhang T, Kunar B, Witherspoon M, Han T, Tedeschi AM, Scottoni F, Lipkin SM, Dow L, Elemento O, Xiang JZ, Shido K, Spence JR, Zhou QJ, Schwartz RE, De Coppi P, Rabbany SY, Rafii S. Palikuqi B, et al. Among authors: dow l. Nature. 2020 Sep;585(7825):426-432. doi: 10.1038/s41586-020-2712-z. Epub 2020 Sep 9. Nature. 2020. PMID: 32908310 Free PMC article.
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.
Bhardwaj P, Iyengar NM, Zahid H, Carter KM, Byun DJ, Choi MH, Sun Q, Savenkov O, Louka C, Liu C, Piloco P, Acosta M, Bareja R, Elemento O, Foronda M, Dow LE, Oshchepkova S, Giri DD, Pollak M, Zhou XK, Hopkins BD, Laughney AM, Frey MK, Ellenson LH, Morrow M, Spector JA, Cantley LC, Brown KA. Bhardwaj P, et al. Sci Transl Med. 2023 Feb 22;15(684):eade1857. doi: 10.1126/scitranslmed.ade1857. Epub 2023 Feb 22. Sci Transl Med. 2023. PMID: 36812344 Free PMC article.
Lineage Reversion Drives WNT Independence in Intestinal Cancer.
Han T, Goswami S, Hu Y, Tang F, Zafra MP, Murphy C, Cao Z, Poirier JT, Khurana E, Elemento O, Hechtman JF, Ganesh K, Yaeger R, Dow LE. Han T, et al. Cancer Discov. 2020 Oct;10(10):1590-1609. doi: 10.1158/2159-8290.CD-19-1536. Epub 2020 Jun 16. Cancer Discov. 2020. PMID: 32546576 Free PMC article.
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC. Yun J, et al. Science. 2015 Dec 11;350(6266):1391-6. doi: 10.1126/science.aaa5004. Epub 2015 Nov 5. Science. 2015. PMID: 26541605 Free PMC article.
Tankyrase inhibition sensitizes cells to CDK4 blockade.
Foronda M, Tarumoto Y, Schatoff EM, Leach BI, Diaz BJ, Zimmerman J, Goswami S, Shusterman M, Vakoc CR, Dow LE. Foronda M, et al. PLoS One. 2019 Dec 31;14(12):e0226645. doi: 10.1371/journal.pone.0226645. eCollection 2019. PLoS One. 2019. PMID: 31891587 Free PMC article.
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil.
Montrose DC, Saha S, Foronda M, McNally EM, Chen J, Zhou XK, Ha T, Krumsiek J, Buyukozkan M, Verma A, Elemento O, Yantiss RK, Chen Q, Gross SS, Galluzzi L, Dow LE, Dannenberg AJ. Montrose DC, et al. Among authors: dow le. Cancer Res. 2021 May 1;81(9):2275-2288. doi: 10.1158/0008-5472.CAN-20-1541. Epub 2021 Feb 1. Cancer Res. 2021. PMID: 33526512 Free PMC article.
A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets.
Li X, Huang CH, Sánchez-Rivera FJ, Kennedy MC, Tschaharganeh DF, Morris JP 4th, Montinaro A, O'Rourke KP, Banito A, Wilkinson JE, Chen CC, Ho YJ, Dow LE, Tian S, Luan W, de Stanchina E, Zhang T, Gray NS, Walczak H, Lowe SW. Li X, et al. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2110557119. doi: 10.1073/pnas.2110557119. Epub 2022 Apr 20. Proc Natl Acad Sci U S A. 2022. PMID: 35442775 Free PMC article.
221 results