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Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes.
Pfefferlé M, Ingoglia G, Schaer CA, Yalamanoglu A, Buzzi R, Dubach IL, Tan G, López-Cano EY, Schulthess N, Hansen K, Humar R, Schaer DJ, Vallelian F. Pfefferlé M, et al. Among authors: humar r. J Clin Invest. 2020 Oct 1;130(10):5576-5590. doi: 10.1172/JCI137282. J Clin Invest. 2020. PMID: 32663195 Free PMC article.
Revisiting the putative role of heme as a trigger of inflammation.
Vallelian F, Schaer CA, Deuel JW, Ingoglia G, Humar R, Buehler PW, Schaer DJ. Vallelian F, et al. Among authors: humar r. Pharmacol Res Perspect. 2018 Mar 30;6(2):e00392. doi: 10.1002/prp2.392. eCollection 2018 Apr. Pharmacol Res Perspect. 2018. PMID: 29610666 Free PMC article.
Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm.
Hugelshofer M, Buzzi RM, Schaer CA, Richter H, Akeret K, Anagnostakou V, Mahmoudi L, Vaccani R, Vallelian F, Deuel JW, Kronen PW, Kulcsar Z, Regli L, Baek JH, Pires IS, Palmer AF, Dennler M, Humar R, Buehler PW, Kircher PR, Keller E, Schaer DJ. Hugelshofer M, et al. Among authors: humar r. J Clin Invest. 2019 Dec 2;129(12):5219-5235. doi: 10.1172/JCI130630. J Clin Invest. 2019. PMID: 31454333 Free PMC article.
Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury.
Akeret K, Buzzi RM, Schaer CA, Thomson BR, Vallelian F, Wang S, Willms J, Sebök M, Held U, Deuel JW, Humar R, Regli L, Keller E, Hugelshofer M, Schaer DJ. Akeret K, et al. Among authors: humar r. J Cereb Blood Flow Metab. 2021 Nov;41(11):3000-3015. doi: 10.1177/0271678X211020629. Epub 2021 Jun 8. J Cereb Blood Flow Metab. 2021. PMID: 34102922 Free PMC article.
Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics.
Buzzi RM, Owczarek CM, Akeret K, Tester A, Pereira N, Butcher R, Brügger-Verdon V, Hardy MP, Illi M, Wassmer A, Vallelian F, Humar R, Hugelshofer M, Buehler PW, Gentinetta T, Schaer DJ. Buzzi RM, et al. Among authors: humar r. Mol Pharm. 2021 Aug 2;18(8):3158-3170. doi: 10.1021/acs.molpharmaceut.1c00433. Epub 2021 Jul 22. Mol Pharm. 2021. PMID: 34292741 Free article.
50 results