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Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
Huo J, Le Bas A, Ruza RR, Duyvesteyn HME, Mikolajek H, Malinauskas T, Tan TK, Rijal P, Dumoux M, Ward PN, Ren J, Zhou D, Harrison PJ, Weckener M, Clare DK, Vogirala VK, Radecke J, Moynié L, Zhao Y, Gilbert-Jaramillo J, Knight ML, Tree JA, Buttigieg KR, Coombes N, Elmore MJ, Carroll MW, Carrique L, Shah PNM, James W, Townsend AR, Stuart DI, Owens RJ, Naismith JH. Huo J, et al. Among authors: owens rj. Nat Struct Mol Biol. 2020 Sep;27(9):846-854. doi: 10.1038/s41594-020-0469-6. Epub 2020 Jul 13. Nat Struct Mol Biol. 2020. PMID: 32661423
The nsp9 replicase protein of SARS-coronavirus, structure and functional insights.
Sutton G, Fry E, Carter L, Sainsbury S, Walter T, Nettleship J, Berrow N, Owens R, Gilbert R, Davidson A, Siddell S, Poon LL, Diprose J, Alderton D, Walsh M, Grimes JM, Stuart DI. Sutton G, et al. Structure. 2004 Feb;12(2):341-53. doi: 10.1016/j.str.2004.01.016. Structure. 2004. PMID: 14962394 Free PMC article.
High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule.
Siebold C, Berrow N, Walter TS, Harlos K, Owens RJ, Stuart DI, Terman JR, Kolodkin AL, Pasterkamp RJ, Jones EY. Siebold C, et al. Among authors: owens rj. Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16836-41. doi: 10.1073/pnas.0504997102. Epub 2005 Nov 7. Proc Natl Acad Sci U S A. 2005. PMID: 16275925 Free PMC article.
Structure of 5-formyltetrahydrofolate cyclo-ligase from Bacillus anthracis (BA4489).
Meier C, Carter LG, Winter G, Owens RJ, Stuart DI, Esnouf RM. Meier C, et al. Among authors: owens rj. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):168-72. doi: 10.1107/S1744309107007221. Epub 2007 Feb 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17329806 Free PMC article.
199 results