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Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects.
Scekic-Zahirovic J, Sanjuan-Ruiz I, Kan V, Megat S, De Rossi P, Dieterlé S, Cassel R, Jamet M, Kessler P, Wiesner D, Tzeplaeff L, Demais V, Sahadevan S, Hembach KM, Muller HP, Picchiarelli G, Mishra N, Antonucci S, Dirrig-Grosch S, Kassubek J, Rasche V, Ludolph A, Boutillier AL, Roselli F, Polymenidou M, Lagier-Tourenne C, Liebscher S, Dupuis L. Scekic-Zahirovic J, et al. Nat Commun. 2021 May 21;12(1):3028. doi: 10.1038/s41467-021-23187-9. Nat Commun. 2021. PMID: 34021132 Free PMC article.
Distinct molecular profiles of skull bone marrow in health and neurological disorders.
Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M, Kapoor S, Bartos LM, Büttner M, Caliskan OS, Rong Z, Mai H, Höher L, Jeridi D, Molbay M, Khalin I, Deligiannis IK, Negwer M, Roberts K, Simats A, Carofiglio O, Todorov MI, Horvath I, Ozturk F, Hummel S, Biechele G, Zatcepin A, Unterrainer M, Gnörich J, Roodselaar J, Shrouder J, Khosravani P, Tast B, Richter L, Díaz-Marugán L, Kaltenecker D, Lux L, Chen Y, Zhao S, Rauchmann BS, Sterr M, Kunze I, Stanic K, Kan VWY, Besson-Girard S, Katzdobler S, Palleis C, Schädler J, Paetzold JC, Liebscher S, Hauser AE, Gokce O, Lickert H, Steinke H, Benakis C, Braun C, Martinez-Jimenez CP, Buerger K, Albert NL, Höglinger G, Levin J, Haass C, Kopczak A, Dichgans M, Havla J, Kümpfel T, Kerschensteiner M, Schifferer M, Simons M, Liesz A, Krahmer N, Bayraktar OA, Franzmeier N, Plesnila N, Erener S, Puelles VG, Delbridge C, Bhatia HS, Hellal F, Elsner M, Bechmann I, Ondruschka B, Brendel M, Theis FJ, Erturk A. Kolabas ZI, et al. Among authors: kan vwy. Cell. 2023 Aug 17;186(17):3706-3725.e29. doi: 10.1016/j.cell.2023.07.009. Epub 2023 Aug 9. Cell. 2023. PMID: 37562402 Free PMC article.
Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency.
Scekic-Zahirovic J, Benetton C, Brunet A, Ye X, Logunov E, Douchamps V, Megat S, Andry V, Kan VWY, Stuart-Lopez G, Gilet J, Guillot SJ, Dirrig-Grosch S, Gorin C, Trombini M, Dieterle S, Sinniger J, Fischer M, René F, Gunes Z, Kessler P, Dupuis L, Pradat PF, Goumon Y, Goutagny R, Marchand-Pauvert V, Liebscher S, Rouaux C. Scekic-Zahirovic J, et al. Among authors: kan vwy. Sci Transl Med. 2024 Mar 13;16(738):eadg3665. doi: 10.1126/scitranslmed.adg3665. Epub 2024 Mar 13. Sci Transl Med. 2024. PMID: 38478631