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The p.P888L SAP97 polymorphism increases the transient outward current (Ito,f) and abbreviates the action potential duration and the QT interval.
Tinaquero D, Crespo-García T, Utrilla RG, Nieto-Marín P, González-Guerra A, Rubio-Alarcón M, Cámara-Checa A, Dago M, Matamoros M, Pérez-Hernández M, Tamargo M, Cebrián J, Jalife J, Tamargo J, Bernal JA, Caballero R, Delpón E; ITACA Investigators. Tinaquero D, et al. Among authors: matamoros m. Sci Rep. 2020 Jul 1;10(1):10707. doi: 10.1038/s41598-020-67109-z. Sci Rep. 2020. PMID: 32612162 Free PMC article.
Tbx20 controls the expression of the KCNH2 gene and of hERG channels.
Caballero R, Utrilla RG, Amorós I, Matamoros M, Pérez-Hernández M, Tinaquero D, Alfayate S, Nieto-Marín P, Guerrero-Serna G, Liu QH, Ramos-Mondragón R, Ponce-Balbuena D, Herron T, Campbell KF, Filgueiras-Rama D, Peinado R, López-Sendón JL, Jalife J, Delpón E, Tamargo J. Caballero R, et al. Among authors: matamoros m. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E416-E425. doi: 10.1073/pnas.1612383114. Epub 2017 Jan 3. Proc Natl Acad Sci U S A. 2017. PMID: 28049825 Free PMC article.
Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore.
Amorós I, Dolz-Gaitón P, Gómez R, Matamoros M, Barana A, de la Fuente MG, Núñez M, Pérez-Hernández M, Moraleda I, Gálvez E, Iriepa I, Tamargo J, Caballero R, Delpón E. Amorós I, et al. Among authors: matamoros m. Biochem Pharmacol. 2013 Jul 15;86(2):267-78. doi: 10.1016/j.bcp.2013.04.023. Epub 2013 May 3. Biochem Pharmacol. 2013. PMID: 23648307
Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current.
Barana A, Matamoros M, Dolz-Gaitón P, Pérez-Hernández M, Amorós I, Núñez M, Sacristán S, Pedraz Á, Pinto Á, Fernández-Avilés F, Tamargo J, Delpón E, Caballero R. Barana A, et al. Among authors: matamoros m. Circ Arrhythm Electrophysiol. 2014 Oct;7(5):861-8. doi: 10.1161/CIRCEP.114.001709. Epub 2014 Aug 8. Circ Arrhythm Electrophysiol. 2014. PMID: 25107449
Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents.
Gómez R, Caballero R, Barana A, Amorós I, De Palm SH, Matamoros M, Núñez M, Pérez-Hernández M, Iriepa I, Tamargo J, Delpón E. Gómez R, et al. Among authors: matamoros m. Cardiovasc Res. 2014 Nov 1;104(2):337-46. doi: 10.1093/cvr/cvu203. Epub 2014 Sep 9. Cardiovasc Res. 2014. PMID: 25205296
Kir2.1-Nav1.5 Channel Complexes Are Differently Regulated than Kir2.1 and Nav1.5 Channels Alone.
Utrilla RG, Nieto-Marín P, Alfayate S, Tinaquero D, Matamoros M, Pérez-Hernández M, Sacristán S, Ondo L, de Andrés R, Díez-Guerra FJ, Tamargo J, Delpón E, Caballero R. Utrilla RG, et al. Among authors: matamoros m. Front Physiol. 2017 Nov 14;8:903. doi: 10.3389/fphys.2017.00903. eCollection 2017. Front Physiol. 2017. PMID: 29184507 Free PMC article.
Cardiac Kir2.1 and NaV1.5 Channels Traffic Together to the Sarcolemma to Control Excitability.
Ponce-Balbuena D, Guerrero-Serna G, Valdivia CR, Caballero R, Diez-Guerra FJ, Jiménez-Vázquez EN, Ramírez RJ, Monteiro da Rocha A, Herron TJ, Campbell KF, Willis BC, Alvarado FJ, Zarzoso M, Kaur K, Pérez-Hernández M, Matamoros M, Valdivia HH, Delpón E, Jalife J. Ponce-Balbuena D, et al. Among authors: matamoros m. Circ Res. 2018 May 25;122(11):1501-1516. doi: 10.1161/CIRCRESAHA.117.311872. Epub 2018 Mar 7. Circ Res. 2018. PMID: 29514831 Free PMC article.
Brugada syndrome trafficking-defective Nav1.5 channels can trap cardiac Kir2.1/2.2 channels.
Pérez-Hernández M, Matamoros M, Alfayate S, Nieto-Marín P, Utrilla RG, Tinaquero D, de Andrés R, Crespo T, Ponce-Balbuena D, Willis BC, Jiménez-Vazquez EN, Guerrero-Serna G, da Rocha AM, Campbell K, Herron TJ, Díez-Guerra FJ, Tamargo J, Jalife J, Caballero R, Delpón E. Pérez-Hernández M, et al. Among authors: matamoros m. JCI Insight. 2018 Sep 20;3(18):e96291. doi: 10.1172/jci.insight.96291. eCollection 2018 Sep 20. JCI Insight. 2018. PMID: 30232268 Free PMC article.
87 results