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Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
Ribeiro JA, Hammer A, Libreros-Zúñiga GA, Chavez-Pacheco SM, Tyrakis P, de Oliveira GS, Kirkman T, El Bakali J, Rocco SA, Sforça ML, Parise-Filho R, Coyne AG, Blundell TL, Abell C, Dias MVB. Ribeiro JA, et al. Among authors: el bakali j. ACS Infect Dis. 2020 Aug 14;6(8):2192-2201. doi: 10.1021/acsinfecdis.0c00263. Epub 2020 Jul 10. ACS Infect Dis. 2020. PMID: 32603583
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design.
Thomas SE, McCarthy WJ, El Bakali J, Brown KP, Kim SY, Blaszczyk M, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Thomas SE, et al. Among authors: el bakali j. Front Mol Biosci. 2022 May 30;9:880432. doi: 10.3389/fmolb.2022.880432. eCollection 2022. Front Mol Biosci. 2022. PMID: 35712348 Free PMC article.
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C. El Bakali J, et al. Angew Chem Weinheim Bergstr Ger. 2023 Apr 17;135(17):e202300221. doi: 10.1002/ange.202300221. Epub 2023 Mar 13. Angew Chem Weinheim Bergstr Ger. 2023. PMID: 38515507 Free PMC article.
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C. El Bakali J, et al. Angew Chem Int Ed Engl. 2023 Apr 17;62(17):e202300221. doi: 10.1002/anie.202300221. Epub 2023 Mar 13. Angew Chem Int Ed Engl. 2023. PMID: 36757665 Free PMC article.
A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration.
Tautou M, Eddarkaoui S, Descamps F, Larchanché PE, El Bakali J, Goveas LM, Dumoulin M, Lamarre C, Blum D, Buée L, Melnyk P, Sergeant N. Tautou M, et al. Among authors: el bakali j. Front Pharmacol. 2021 Jun 29;12:679335. doi: 10.3389/fphar.2021.679335. eCollection 2021. Front Pharmacol. 2021. PMID: 34267657 Free PMC article.
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors.
Gay M, Evrard C, Descamps F, Carato P, Renault N, Coevoet M, Eddarkaoui S, Baud C, Larchanché PE, Buée L, El Bakali J, Vingtdeux V, Sergeant N, Melnyk P. Gay M, et al. Among authors: el bakali j. Eur J Med Chem. 2018 Nov 5;159:104-125. doi: 10.1016/j.ejmech.2018.08.092. Epub 2018 Sep 22. Eur J Med Chem. 2018. PMID: 30268822
17 results