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The autoimmune susceptibility gene, PTPN2, restricts expansion of a novel mouse adherent-invasive E. coli.
Shawki A, Ramirez R, Spalinger MR, Ruegger PM, Sayoc-Becerra A, Santos AN, Chatterjee P, Canale V, Mitchell JD, Macbeth JC, Gries CM, Tremblay ML, Hsiao A, Borneman J, McCole DF. Shawki A, et al. Among authors: tremblay ml. Gut Microbes. 2020 Nov 1;11(6):1547-1566. doi: 10.1080/19490976.2020.1775538. Epub 2020 Jun 26. Gut Microbes. 2020. PMID: 32586195 Free PMC article.
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.
Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N. Svensson MN, et al. Among authors: tremblay ml. J Clin Invest. 2019 Mar 1;129(3):1193-1210. doi: 10.1172/JCI123267. Epub 2019 Feb 11. J Clin Invest. 2019. PMID: 30620725 Free PMC article.
Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells.
Spalinger MR, Hai R, Li J, Santos AN, Nordgren TM, Tremblay ML, Eckmann L, Hanson E, Scharl M, Wu X, Boland BS, McCole DF. Spalinger MR, et al. Among authors: tremblay ml. bioRxiv [Preprint]. 2020 Dec 9:2020.12.09.416586. doi: 10.1101/2020.12.09.416586. bioRxiv. 2020. PMID: 33330862 Free PMC article. Preprint.
T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.
Marchelletta RR, Krishnan M, Spalinger MR, Placone TW, Alvarez R, Sayoc-Becerra A, Canale V, Shawki A, Park YS, Bernts LH, Myers S, Tremblay ML, Barrett KE, Krystofiak E, Kachar B, McGovern DP, Weber CR, Hanson EM, Eckmann L, McCole DF. Marchelletta RR, et al. Among authors: tremblay ml. J Clin Invest. 2021 Sep 1;131(17):e138230. doi: 10.1172/JCI138230. J Clin Invest. 2021. PMID: 34623320 Free PMC article.
Beyond the metabolic function of PTP1B.
Dubé N, Tremblay ML. Dubé N, et al. Among authors: tremblay ml. Cell Cycle. 2004 May;3(5):550-3. Epub 2004 May 10. Cell Cycle. 2004. PMID: 15044856
245 results