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Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer.
Li L, Hobson L, Perry L, Clark B, Heavey S, Haider A, Sridhar A, Shaw G, Kelly J, Freeman A, Wilson I, Whitaker H, Nurmemmedov E, Oltean S, Porazinski S, Ladomery M. Li L, et al. Among authors: oltean s. Br J Cancer. 2020 Sep;123(6):1024-1032. doi: 10.1038/s41416-020-0951-2. Epub 2020 Jun 25. Br J Cancer. 2020. PMID: 32581342 Free PMC article.
WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.
Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, Welsh GI, Cheung MK, Ni L, Kase S, Rennel ES, Symonds KE, Nowak DG, Royer-Pokora B, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton DR, Bates DO, Ladomery MR. Amin EM, et al. Among authors: oltean s. Cancer Cell. 2011 Dec 13;20(6):768-80. doi: 10.1016/j.ccr.2011.10.016. Cancer Cell. 2011. PMID: 22172722 Free PMC article.
The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor.
Legge D, Li L, Moriarty W, Lee D, Szemes M, Zahed A, Panousopoulos L, Chung WY, Aghabi Y, Barratt J, Williams R, Pritchard-Jones K, Malik KTA, Oltean S, Brown KW. Legge D, et al. Among authors: oltean s. Mol Oncol. 2022 Feb;16(3):630-647. doi: 10.1002/1878-0261.13101. Epub 2021 Sep 28. Mol Oncol. 2022. PMID: 34520622 Free PMC article.
60 results