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Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.
Schober R, Bonhenry D, Lunz V, Zhu J, Krizova A, Frischauf I, Fahrner M, Zhang M, Waldherr L, Schmidt T, Derler I, Stathopulos PB, Romanin C, Ettrich RH, Schindl R. Schober R, et al. Among authors: bonhenry d. Sci Signal. 2019 Nov 19;12(608):eaax3194. doi: 10.1126/scisignal.aax3194. Sci Signal. 2019. PMID: 31744929
Twisting gating residues in the Orai pore.
Bonhenry D, Schober R, Schindl R. Bonhenry D, et al. Cell Calcium. 2021 Jan;93:102323. doi: 10.1016/j.ceca.2020.102323. Epub 2020 Dec 2. Cell Calcium. 2021. PMID: 33316586
CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions.
Tiffner A, Schober R, Höglinger C, Bonhenry D, Pandey S, Lunz V, Sallinger M, Frischauf I, Fahrner M, Lindinger S, Maltan L, Berlansky S, Stadlbauer M, Schindl R, Ettrich R, Romanin C, Derler I. Tiffner A, et al. Among authors: bonhenry d. J Biol Chem. 2021 Jan-Jun;296:100224. doi: 10.1074/jbc.RA120.015548. Epub 2020 Dec 29. J Biol Chem. 2021. PMID: 33361160 Free PMC article.
Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.
Frischauf I, Litviňuková M, Schober R, Zayats V, Svobodová B, Bonhenry D, Lunz V, Cappello S, Tociu L, Reha D, Stallinger A, Hochreiter A, Pammer T, Butorac C, Muik M, Groschner K, Bogeski I, Ettrich RH, Romanin C, Schindl R. Frischauf I, et al. Among authors: bonhenry d. Sci Signal. 2017 Nov 28;10(507):eaao0358. doi: 10.1126/scisignal.aao0358. Sci Signal. 2017. PMID: 29184031 Free PMC article.
Blockage of Store-Operated Ca2+ Influx by Synta66 is Mediated by Direct Inhibition of the Ca2+ Selective Orai1 Pore.
Waldherr L, Tiffner A, Mishra D, Sallinger M, Schober R, Frischauf I, Schmidt T, Handl V, Sagmeister P, Köckinger M, Derler I, Üçal M, Bonhenry D, Patz S, Schindl R. Waldherr L, et al. Among authors: bonhenry d. Cancers (Basel). 2020 Oct 6;12(10):2876. doi: 10.3390/cancers12102876. Cancers (Basel). 2020. PMID: 33036292 Free PMC article.
17 results