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A physiologically based pharmacokinetic (PBPK) parent-metabolite model of the chemotherapeutic zoptarelin doxorubicin-integration of in vitro results, Phase I and Phase II data and model application for drug-drug interaction potential analysis.
Hanke N, Teifel M, Moj D, Wojtyniak JG, Britz H, Aicher B, Sindermann H, Ammer N, Lehr T. Hanke N, et al. Among authors: lehr t. Cancer Chemother Pharmacol. 2018 Feb;81(2):291-304. doi: 10.1007/s00280-017-3495-2. Epub 2017 Dec 4. Cancer Chemother Pharmacol. 2018. PMID: 29204687 Clinical Trial.
Population nutrikinetics of green tea extract.
Scholl C, Lepper A, Lehr T, Hanke N, Schneider KL, Brockmöller J, Seufferlein T, Stingl JC. Scholl C, et al. Among authors: lehr t. PLoS One. 2018 Feb 21;13(2):e0193074. doi: 10.1371/journal.pone.0193074. eCollection 2018. PLoS One. 2018. PMID: 29466429 Free PMC article. Clinical Trial.
Physiologically-Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam.
Britz H, Hanke N, Volz AK, Spigset O, Schwab M, Eissing T, Wendl T, Frechen S, Lehr T. Britz H, et al. Among authors: lehr t. CPT Pharmacometrics Syst Pharmacol. 2019 May;8(5):296-307. doi: 10.1002/psp4.12397. Epub 2019 Mar 13. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30762305 Free PMC article.
Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug-Drug-Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole.
Türk D, Hanke N, Wolf S, Frechen S, Eissing T, Wendl T, Schwab M, Lehr T. Türk D, et al. Among authors: lehr t. Clin Pharmacokinet. 2019 Dec;58(12):1595-1607. doi: 10.1007/s40262-019-00777-x. Clin Pharmacokinet. 2019. PMID: 31129789 Free PMC article.
Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences.
Lippert J, Burghaus R, Edginton A, Frechen S, Karlsson M, Kovar A, Lehr T, Milligan P, Nock V, Ramusovic S, Riggs M, Schaller S, Schlender J, Schmidt S, Sevestre M, Sjögren E, Solodenko J, Staab A, Teutonico D. Lippert J, et al. Among authors: lehr t. CPT Pharmacometrics Syst Pharmacol. 2019 Dec;8(12):878-882. doi: 10.1002/psp4.12473. Epub 2019 Nov 12. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31671256 Free PMC article. Review. No abstract available.
133 results