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Identification of a G-Protein-Independent Activator of GIRK Channels.
Zhao Y, Ung PM, Zahoránszky-Kőhalmi G, Zakharov AV, Martinez NJ, Simeonov A, Glaaser IW, Rai G, Schlessinger A, Marugan JJ, Slesinger PA. Zhao Y, et al. Among authors: martinez nj. Cell Rep. 2020 Jun 16;31(11):107770. doi: 10.1016/j.celrep.2020.107770. Cell Rep. 2020. PMID: 32553165 Free PMC article.
A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.
Martinez NJ, Rai G, Yasgar A, Lea WA, Sun H, Wang Y, Luci DK, Yang SM, Nishihara K, Takeda S, Sagor M, Earnshaw I, Okada T, Mori K, Wilson K, Riggins GJ, Xia M, Grimaldi M, Jadhav A, Maloney DJ, Simeonov A. Martinez NJ, et al. PLoS One. 2016 Aug 29;11(8):e0161486. doi: 10.1371/journal.pone.0161486. eCollection 2016. PLoS One. 2016. PMID: 27570969 Free PMC article.
Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.
Urban DJ, Martinez NJ, Davis MI, Brimacombe KR, Cheff DM, Lee TD, Henderson MJ, Titus SA, Pragani R, Rohde JM, Liu L, Fang Y, Karavadhi S, Shah P, Lee OW, Wang A, McIver A, Zheng H, Wang X, Xu X, Jadhav A, Simeonov A, Shen M, Boxer MB, Hall MD. Urban DJ, et al. Among authors: martinez nj. Sci Rep. 2017 Oct 6;7(1):12758. doi: 10.1038/s41598-017-12630-x. Sci Rep. 2017. PMID: 28986582 Free PMC article.
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
Shen M, Asawa R, Zhang YQ, Cunningham E, Sun H, Tropsha A, Janzen WP, Muratov EN, Capuzzi SJ, Farag S, Jadhav A, Blatt J, Simeonov A, Martinez NJ. Shen M, et al. Among authors: martinez nj. Oncotarget. 2017 Dec 19;9(4):4758-4772. doi: 10.18632/oncotarget.23462. eCollection 2018 Jan 12. Oncotarget. 2017. PMID: 29435139 Free PMC article.
Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models.
Yu L, Zhang X, Yang Y, Li D, Tang K, Zhao Z, He W, Wang C, Sahoo N, Converso-Baran K, Davis CS, Brooks SV, Bigot A, Calvo R, Martinez NJ, Southall N, Hu X, Marugan J, Ferrer M, Xu H. Yu L, et al. Among authors: martinez nj. Sci Adv. 2020 Feb 7;6(6):eaaz2736. doi: 10.1126/sciadv.aaz2736. eCollection 2020 Feb. Sci Adv. 2020. PMID: 32128386 Free PMC article.
68 results