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Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C. El Bakali J, et al. Among authors: abell c. Angew Chem Weinheim Bergstr Ger. 2023 Apr 17;135(17):e202300221. doi: 10.1002/ange.202300221. Epub 2023 Mar 13. Angew Chem Weinheim Bergstr Ger. 2023. PMID: 38515507 Free PMC article.
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target.
Howieson VM, Zeng J, Kloehn J, Spry C, Marchetti C, Lunghi M, Varesio E, Soper A, Coyne AG, Abell C, van Dooren GG, Saliba KJ. Howieson VM, et al. Among authors: abell c. Int J Parasitol Drugs Drug Resist. 2023 Aug;22:1-8. doi: 10.1016/j.ijpddr.2023.03.003. Epub 2023 Mar 15. Int J Parasitol Drugs Drug Resist. 2023. PMID: 37004488 Free PMC article.
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C. El Bakali J, et al. Among authors: abell c. Angew Chem Int Ed Engl. 2023 Apr 17;62(17):e202300221. doi: 10.1002/anie.202300221. Epub 2023 Mar 13. Angew Chem Int Ed Engl. 2023. PMID: 36757665 Free PMC article.
Development of potent inhibitors by fragment-linking strategies.
Bedwell EV, McCarthy WJ, Coyne AG, Abell C. Bedwell EV, et al. Among authors: abell c. Chem Biol Drug Des. 2022 Oct;100(4):469-486. doi: 10.1111/cbdd.14120. Epub 2022 Aug 16. Chem Biol Drug Des. 2022. PMID: 35854428 Review.
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design.
Thomas SE, McCarthy WJ, El Bakali J, Brown KP, Kim SY, Blaszczyk M, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Thomas SE, et al. Among authors: abell c. Front Mol Biosci. 2022 May 30;9:880432. doi: 10.3389/fmolb.2022.880432. eCollection 2022. Front Mol Biosci. 2022. PMID: 35712348 Free PMC article.
401 results