Durk MR - Search Results

1

Understanding the Effect of Hydroxypropyl-β-Cyclodextrin on Fenebrutinib Absorption in an Itraconazole-Fenebrutinib Drug-Drug Interaction Study.

Durk MR, Jones NS, Liu J, Nagapudi K, Mao C, Plise EG, Wong S, Chen JZ, Chen Y, Chinn LW, Chiang PC. Durk MR, et al. Clin Pharmacol Ther. 2020 Dec;108(6):1224-1232. doi: 10.1002/cpt.1943. Epub 2020 Jul 18. Clin Pharmacol Ther. 2020. PMID: 32535897 Free PMC article.

2

Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.

Fan PW, Chen JZ, Allan Jaochico M, La H, Liu N, Mulder T, Cass RT, Durk M, Messick K, Valle N, Liu S, Lee W, Crawford JJ, Rudolf J, Murray LJ, Cyrus Khojasteh S, Wright M. Fan PW, et al. Drug Metab Lett. 2016;10(2):91-100. doi: 10.2174/1872312810666160411144358. Drug Metab Lett. 2016. PMID: 27063863 Free PMC article.

3

Biorelevant Dissolution Models for a Weak Base To Facilitate Formulation Development and Overcome Reduced Bioavailability Caused by Hypochlordyria or Achlorhydria.

Kou D, Dwaraknath S, Fischer Y, Nguyen D, Kim M, Yiu H, Patel P, Ng T, Mao C, Durk M, Chinn L, Winter H, Wigman L, Yehl P. Kou D, et al. Mol Pharm. 2017 Oct 2;14(10):3577-3587. doi: 10.1021/acs.molpharmaceut.7b00593. Epub 2017 Sep 8. Mol Pharm. 2017. PMID: 28834434

4

In Vitro, in Silico, and in Vivo Assessments of Intestinal Precipitation and Its Impact on Bioavailability of a BCS Class 2 Basic Compound.

Kou D, Zhang C, Yiu H, Ng T, Lubach JW, Janson M, Mao C, Durk M, Chinn L, Winter H, Wigman L, Yehl P. Kou D, et al. Mol Pharm. 2018 Apr 2;15(4):1607-1617. doi: 10.1021/acs.molpharmaceut.7b01143. Epub 2018 Mar 19. Mol Pharm. 2018. PMID: 29522347

5

Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI.

Jones NS, Yoshida K, Salphati L, Kenny JR, Durk MR, Chinn LW. Jones NS, et al. Among authors: durk mr. Clin Pharmacol Ther. 2020 Jan;107(1):269-277. doi: 10.1002/cpt.1599. Epub 2019 Sep 16. Clin Pharmacol Ther. 2020. PMID: 31376152 Free PMC article. Clinical Trial.

6

Evaluating the Pharmacokinetics and Systemic Effects of a Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl)amino] Caprylate in Rats.

Chiang PC, Deshmukh G, Liu J, Nagapudi K, Chen JZ, Valle N, Li R, Plise EG, Durk MR. Chiang PC, et al. Among authors: durk mr. J Pharm Sci. 2020 Aug;109(8):2629-2636. doi: 10.1016/j.xphs.2020.04.016. Epub 2020 Apr 28. J Pharm Sci. 2020. PMID: 32360544

7

Physiologically-Based Pharmacokinetic Model-Informed Drug Development for Fenebrutinib: Understanding Complex Drug-Drug Interactions.

Chen Y, Ma F, Jones NS, Yoshida K, Chiang PC, Durk MR, Wright MR, Jin JY, Chinn LW. Chen Y, et al. Among authors: durk mr. CPT Pharmacometrics Syst Pharmacol. 2020 Jun;9(6):332-341. doi: 10.1002/psp4.12515. Epub 2020 May 29. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32383787 Free PMC article.

8

Elucidating a Potential Mechanism of Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl) amino] Caprylate in Rats: Evidence of Lymphatic Absorption of Cyanocobalamin using the Mesenteric Lymph Duct Cannulated Rat.

Chiang PC, Liu J, Nagapudi K, Wu R, Dolton M, Chen J, Plise E, Liu L, Durk MR. Chiang PC, et al. Among authors: durk mr. J Pharm Sci. 2022 Dec;111(12):3417-3423. doi: 10.1016/j.xphs.2022.10.003. Epub 2022 Oct 11. J Pharm Sci. 2022. PMID: 36228756

9

Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2).

Zeng M, Grandner JM, Bryan MC, Verma V, Larouche-Gauthier R, Leclerc JP, Zhao L, Haghshenas P, Aubert-Nicol S, Yadav A, Ashley M, Chen JZ, Durk M, Samy KE, Nespi M, Levy E, Merrick K, Moffat JG, Murray J, Oh A, Orr C, Segal E, Sims J, Sneeringer C, Prangley M, Vartanian S, Magnuson S, Parr BT. Zeng M, et al. ACS Med Chem Lett. 2023 Aug 24;14(9):1179-1187. doi: 10.1021/acsmedchemlett.3c00142. eCollection 2023 Sep 14. ACS Med Chem Lett. 2023. PMID: 37736184

10

Quantitative Intracerebral Microdialysis Studies to Determine Unbound Extracellular Fluid Drug Concentrations in Discrete Areas of the Brain.

Durk MR. Durk MR. Curr Protoc Pharmacol. 2018 Mar;80(1):7.18.1-7.18.19. doi: 10.1002/cpph.38. Curr Protoc Pharmacol. 2018. PMID: 30040217

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