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ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation.
Soulet F, Bodineau C, Hooks KB, Descarpentrie J, Alves I, Dubreuil M, Mouchard A, Eugenie M, Hoepffner JL, López JJ, Rosado JA, Soubeyran I, Tomé M, Durán RV, Nikolski M, Villoutreix BO, Evrard S, Siegfried G, Khatib AM. Soulet F, et al. Among authors: tome m. JCI Insight. 2020 Jul 23;5(14):e129070. doi: 10.1172/jci.insight.129070. JCI Insight. 2020. PMID: 32516140 Free PMC article.
mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells.
Nguyen TL, Nokin MJ, Egorov M, Tomé M, Bodineau C, Di Primo C, Minder L, Wdzieczak-Bakala J, Garcia-Alvarez MC, Bignon J, Thoison O, Delpech B, Surpateanu G, Frapart YM, Peyrot F, Abbas K, Terés S, Evrard S, Khatib AM, Soubeyran P, Iorga BI, Durán RV, Collin P. Nguyen TL, et al. Among authors: tome m. Cancer Res. 2018 Sep 15;78(18):5384-5397. doi: 10.1158/0008-5472.CAN-18-0232. Epub 2018 Jul 27. Cancer Res. 2018. PMID: 30054335
Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer.
Tomé M, Pappalardo A, Soulet F, López JJ, Olaizola J, Leger Y, Dubreuil M, Mouchard A, Fessart D, Delom F, Pitard V, Bechade D, Fonck M, Rosado JA, Ghiringhelli F, Déchanet-Merville J, Soubeyran I, Siegfried G, Evrard S, Khatib AM. Tomé M, et al. Cancer Res. 2019 Oct 1;79(19):5008-5021. doi: 10.1158/0008-5472.CAN-19-0086. Epub 2019 Jul 29. Cancer Res. 2019. PMID: 31358531
Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia.
Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV. Nguyen TL, et al. Among authors: tome m. Mol Oncol. 2021 May;15(5):1412-1431. doi: 10.1002/1878-0261.12877. Epub 2021 Feb 13. Mol Oncol. 2021. PMID: 33314742 Free PMC article.
Glutaminolysis-induced mTORC1 activation drives non-alcoholic steatohepatitis progression.
Cabré N, Luciano-Mateo F, Chapski DJ, Baiges-Gaya G, Fernández-Arroyo S, Hernández-Aguilera A, Castañé H, Rodríguez-Tomàs E, París M, Sabench F, Del Castillo D, Del Bas JM, Tomé M, Bodineau C, Sola-García A, López-Miranda J, Martín-Montalvo A, Durán RV, Vondriska TM, Rosa-Garrido M, Camps J, Menéndez JA, Joven J. Cabré N, et al. Among authors: tome m. J Hepatol. 2021 May 4:S0168-8278(21)00302-0. doi: 10.1016/j.jhep.2021.04.037. Online ahead of print. J Hepatol. 2021. PMID: 33961941 Free article.
Glutamine, MTOR and autophagy: a multiconnection relationship.
Bodineau C, Tomé M, Murdoch PDS, Durán RV. Bodineau C, et al. Among authors: tome m. Autophagy. 2022 Nov;18(11):2749-2750. doi: 10.1080/15548627.2022.2062875. Epub 2022 Apr 26. Autophagy. 2022. PMID: 35470752 Free PMC article.
Laparoscopic Sleeve Gastrectomy in Patients with Severe Obesity Restores Adaptive Responses Leading to Nonalcoholic Steatohepatitis.
Cabré N, Luciano-Mateo F, Chapski DJ, Baiges-Gaya G, Fernández-Arroyo S, Hernández-Aguilera A, Castañé H, Rodríguez-Tomàs E, París M, Sabench F, Castillo DD, Del Bas JM, Tomé M, Bodineau C, Sola-García A, López-Miranda J, Martín-Montalvo A, Durán RV, Vondriska TM, Rosa-Garrido M, Camps J, Menéndez JA, Joven J. Cabré N, et al. Among authors: tome m. Int J Mol Sci. 2022 Jul 15;23(14):7830. doi: 10.3390/ijms23147830. Int J Mol Sci. 2022. PMID: 35887177 Free PMC article.
Manganese is a physiologically relevant TORC1 activator in yeast and mammals.
Nicastro R, Gaillard H, Zarzuela L, Péli-Gulli MP, Fernández-García E, Tomé M, García-Rodríguez N, Durán RV, De Virgilio C, Wellinger RE. Nicastro R, et al. Among authors: tome m. Elife. 2022 Jul 29;11:e80497. doi: 10.7554/eLife.80497. Elife. 2022. PMID: 35904415 Free PMC article.
286 results