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Spermine promotes pulmonary vascular remodelling and its synthase is a therapeutic target for pulmonary arterial hypertension.
He YY, Yan Y, Jiang X, Zhao JH, Wang Z, Wu T, Wang Y, Guo SS, Ye J, Lian TY, Xu XQ, Zhang JL, Sun K, Peng FH, Zhou YP, Mao YM, Zhang X, Chen JW, Zhang SY, Jing ZC. He YY, et al. Among authors: chen jw. Eur Respir J. 2020 Nov 5;56(5):2000522. doi: 10.1183/13993003.00522-2020. Print 2020 Nov. Eur Respir J. 2020. PMID: 32513782 Free article.
Upregulated copper transporters in hypoxia-induced pulmonary hypertension.
Zimnicka AM, Tang H, Guo Q, Kuhr FK, Oh MJ, Wan J, Chen J, Smith KA, Fraidenburg DR, Choudhury MS, Levitan I, Machado RF, Kaplan JH, Yuan JX. Zimnicka AM, et al. PLoS One. 2014 Mar 10;9(3):e90544. doi: 10.1371/journal.pone.0090544. eCollection 2014. PLoS One. 2014. PMID: 24614111 Free PMC article.
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Chen J, Tang H, Sysol JR, Moreno-Vinasco L, Shioura KM, Chen T, Gorshkova I, Wang L, Huang LS, Usatyuk PV, Sammani S, Zhou G, Raj JU, Garcia JG, Berdyshev E, Yuan JX, Natarajan V, Machado RF. Chen J, et al. Am J Respir Crit Care Med. 2014 Nov 1;190(9):1032-43. doi: 10.1164/rccm.201401-0121OC. Am J Respir Crit Care Med. 2014. PMID: 25180446 Free PMC article.
Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.
Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX. Tang H, et al. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L208-20. doi: 10.1152/ajplung.00242.2014. Epub 2014 Nov 21. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25416384 Free PMC article.
Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.
Chen J, Sysol JR, Singla S, Zhao S, Yamamura A, Valdez-Jasso D, Abbasi T, Shioura KM, Sahni S, Reddy V, Sridhar A, Gao H, Torres J, Camp SM, Tang H, Ye SQ, Comhair S, Dweik R, Hassoun P, Yuan JX, Garcia JGN, Machado RF. Chen J, et al. Circulation. 2017 Apr 18;135(16):1532-1546. doi: 10.1161/CIRCULATIONAHA.116.024557. Epub 2017 Feb 15. Circulation. 2017. PMID: 28202489 Free PMC article.
2,012 results