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MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment.
de Wilde AH, Raj VS, Oudshoorn D, Bestebroer TM, van Nieuwkoop S, Limpens RWAL, Posthuma CC, van der Meer Y, Bárcena M, Haagmans BL, Snijder EJ, van den Hoogen BG. de Wilde AH, et al. J Gen Virol. 2013 Aug;94(Pt 8):1749-1760. doi: 10.1099/vir.0.052910-0. Epub 2013 Apr 25. J Gen Virol. 2013. PMID: 23620378 Free PMC article.
Host Factors in Coronavirus Replication.
de Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ. de Wilde AH, et al. Curr Top Microbiol Immunol. 2018;419:1-42. doi: 10.1007/82_2017_25. Curr Top Microbiol Immunol. 2018. PMID: 28643204 Free PMC article. Review.
Cyclosporin A inhibits the replication of diverse coronaviruses.
de Wilde AH, Zevenhoven-Dobbe JC, van der Meer Y, Thiel V, Narayanan K, Makino S, Snijder EJ, van Hemert MJ. de Wilde AH, et al. J Gen Virol. 2011 Nov;92(Pt 11):2542-2548. doi: 10.1099/vir.0.034983-0. Epub 2011 Jul 13. J Gen Virol. 2011. PMID: 21752960 Free PMC article.
Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.
de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ. de Wilde AH, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84. doi: 10.1128/AAC.03011-14. Epub 2014 May 19. Antimicrob Agents Chemother. 2014. PMID: 24841269 Free PMC article.
A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins.
de Wilde AH, Wannee KF, Scholte FE, Goeman JJ, Ten Dijke P, Snijder EJ, Kikkert M, van Hemert MJ. de Wilde AH, et al. J Virol. 2015 Aug;89(16):8318-33. doi: 10.1128/JVI.01029-15. Epub 2015 Jun 3. J Virol. 2015. PMID: 26041291 Free PMC article.
18 results