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Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease.
Griñán-Ferré C, Codony S, Pujol E, Yang J, Leiva R, Escolano C, Puigoriol-Illamola D, Companys-Alemany J, Corpas R, Sanfeliu C, Pérez B, Loza MI, Brea J, Morisseau C, Hammock BD, Vázquez S, Pallàs M, Galdeano C. Griñán-Ferré C, et al. Among authors: galdeano c. Neurotherapeutics. 2020 Oct;17(4):1825-1835. doi: 10.1007/s13311-020-00854-1. Neurotherapeutics. 2020. PMID: 32488482 Free PMC article.
Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates.
Viayna E, Gómez T, Galdeano C, Ramírez L, Ratia M, Badia A, Clos MV, Verdaguer E, Junyent F, Camins A, Pallàs M, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodríguez-Franco MI, Bidon-Chanal A, Luque FJ, Camps P, Muñoz-Torrero D. Viayna E, et al. Among authors: galdeano c. ChemMedChem. 2010 Nov 8;5(11):1855-70. doi: 10.1002/cmdc.201000322. ChemMedChem. 2010. PMID: 20859987
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.
Pérez-Areales FJ, Di Pietro O, Espargaró A, Vallverdú-Queralt A, Galdeano C, Ragusa IM, Viayna E, Guillou C, Clos MV, Pérez B, Sabaté R, Lamuela-Raventós RM, Luque FJ, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: galdeano c. Bioorg Med Chem. 2014 Oct 1;22(19):5298-307. doi: 10.1016/j.bmc.2014.07.053. Epub 2014 Aug 7. Bioorg Med Chem. 2014. PMID: 25156301
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Sola I, Castellà S, Viayna E, Galdeano C, Taylor MC, Gbedema SY, Pérez B, Clos MV, Jones DC, Fairlamb AH, Wright CW, Kelly JM, Muñoz-Torrero D. Sola I, et al. Among authors: galdeano c. Bioorg Med Chem. 2015 Aug 15;23(16):5156-67. doi: 10.1016/j.bmc.2015.01.031. Epub 2015 Jan 24. Bioorg Med Chem. 2015. PMID: 25678015
Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space.
Piticchio SG, Martínez-Cartró M, Scaffidi S, Rachman M, Rodriguez-Arevalo S, Sanchez-Arfelis A, Escolano C, Picaud S, Krojer T, Filippakopoulos P, von Delft F, Galdeano C, Barril X. Piticchio SG, et al. Among authors: galdeano c. J Med Chem. 2021 Dec 23;64(24):17887-17900. doi: 10.1021/acs.jmedchem.1c01108. Epub 2021 Dec 13. J Med Chem. 2021. PMID: 34898210
Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress.
Peyman M, Barroso E, Turcu AL, Estrany F Jr, Smith D, Jurado-Aguilar J, Rada P, Morisseau C, Hammock BD, Valverde ÁM, Palomer X, Galdeano C, Vázquez S, Vázquez-Carrera M. Peyman M, et al. Among authors: galdeano c. Biomed Pharmacother. 2023 Dec;168:115667. doi: 10.1016/j.biopha.2023.115667. Epub 2023 Oct 10. Biomed Pharmacother. 2023. PMID: 37826940 Free article.
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Camps P, Formosa X, Galdeano C, Gómez T, Muñoz-Torrero D, Scarpellini M, Viayna E, Badia A, Clos MV, Camins A, Pallàs M, Bartolini M, Mancini F, Andrisano V, Estelrich J, Lizondo M, Bidon-Chanal A, Luque FJ. Camps P, et al. Among authors: galdeano c. J Med Chem. 2008 Jun 26;51(12):3588-98. doi: 10.1021/jm8001313. Epub 2008 Jun 3. J Med Chem. 2008. PMID: 18517184
41 results