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Saturation of SERCA's lipid annulus may protect against its thermal inactivation.
Fajardo VA, Trojanowski N, Castelli LM, Miotto PM, Amoye F, Ward WE, Tupling AR, LeBlanc PJ. Fajardo VA, et al. Among authors: castelli lm. Biochem Biophys Res Commun. 2017 Mar 4;484(2):456-460. doi: 10.1016/j.bbrc.2017.01.154. Epub 2017 Jan 27. Biochem Biophys Res Commun. 2017. PMID: 28137585
The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function.
Mihaylov SR, Castelli LM, Lin YH, Gül A, Soni N, Hastings C, Flynn HR, Păun O, Dickman MJ, Snijders AP, Goldstone R, Bandmann O, Shelkovnikova TA, Mortiboys H, Ultanir SK, Hautbergue GM. Mihaylov SR, et al. Among authors: castelli lm. Nat Commun. 2023 Sep 7;14(1):5496. doi: 10.1038/s41467-023-41304-8. Nat Commun. 2023. PMID: 37679383 Free PMC article.
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Allen SP, Al Sultan A, Kabucho Kibirige E, Tonkiss E, Hamer KJ, Castelli LM, Lin YH, Roscoe S, Stefanidis N, Mead RJ, Highley JR, Cooper-Knock J, Hautbergue GM, Heath PR, Kirby J, Shaw PJ. Allen SP, et al. Among authors: castelli lm. Front Aging Neurosci. 2023 May 11;15:1151848. doi: 10.3389/fnagi.2023.1151848. eCollection 2023. Front Aging Neurosci. 2023. PMID: 37251807 Free PMC article.
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.
Castelli LM, Lin YH, Sanchez-Martinez A, Gül A, Mohd Imran K, Higginbottom A, Upadhyay SK, Márkus NM, Rua Martins R, Cooper-Knock J, Montmasson C, Cohen R, Walton A, Bauer CS, De Vos KJ, Mead RJ, Azzouz M, Dominguez C, Ferraiuolo L, Shaw PJ, Whitworth AJ, Hautbergue GM. Castelli LM, et al. Sci Transl Med. 2023 Mar;15(685):eabo3823. doi: 10.1126/scitranslmed.abo3823. Epub 2023 Mar 1. Sci Transl Med. 2023. PMID: 36857431
33 results