Assimon VA - Search Results

1

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.

Kariolis MS, Wells RC, Getz JA, Kwan W, Mahon CS, Tong R, Kim DJ, Srivastava A, Bedard C, Henne KR, Giese T, Assimon VA, Chen X, Zhang Y, Solanoy H, Jenkins K, Sanchez PE, Kane L, Miyamoto T, Chew KS, Pizzo ME, Liang N, Calvert MEK, DeVos SL, Baskaran S, Hall S, Sweeney ZK, Thorne RG, Watts RJ, Dennis MS, Silverman AP, Zuchero YJY. Kariolis MS, et al. Among authors: assimon va. Sci Transl Med. 2020 May 27;12(545):eaay1359. doi: 10.1126/scitranslmed.aay1359. Sci Transl Med. 2020. PMID: 32461332

2

Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells.

Taylor IR, Assimon VA, Kuo SY, Rinaldi S, Li X, Young ZT, Morra G, Green K, Nguyen D, Shao H, Garneau-Tsodikova S, Colombo G, Gestwicki JE. Taylor IR, et al. Among authors: assimon va. Chem Sci. 2020 Jan 10;11(7):1892-1904. doi: 10.1039/c9sc04284a. Chem Sci. 2020. PMID: 34123282 Free PMC article.

3

A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions.

Rinaldi S, Assimon VA, Young ZT, Morra G, Shao H, Taylor IR, Gestwicki JE, Colombo G. Rinaldi S, et al. Among authors: assimon va. ACS Chem Biol. 2018 Nov 16;13(11):3142-3152. doi: 10.1021/acschembio.8b00712. Epub 2018 Nov 8. ACS Chem Biol. 2018. PMID: 30372610 Free PMC article.

4

Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity.

Assimon VA, Shao H, Garneau-Tsodikova S, Gestwicki JE. Assimon VA, et al. Medchemcomm. 2015 May 1;6(5):912-918. doi: 10.1039/C4MD00572D. Epub 2015 Mar 30. Medchemcomm. 2015. PMID: 27087913 Free PMC article.

5

Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.

Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. Young ZT, et al. Among authors: assimon va. Cell Chem Biol. 2016 Aug 18;23(8):992-1001. doi: 10.1016/j.chembiol.2016.04.014. Epub 2016 Aug 4. Cell Chem Biol. 2016. PMID: 27499529 Free PMC article.

6

High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex.

Taylor IR, Dunyak BM, Komiyama T, Shao H, Ran X, Assimon VA, Kalyanaraman C, Rauch JN, Jacobson MP, Zuiderweg ERP, Gestwicki JE. Taylor IR, et al. Among authors: assimon va. J Biol Chem. 2018 Mar 16;293(11):4014-4025. doi: 10.1074/jbc.RA117.001575. Epub 2018 Feb 2. J Biol Chem. 2018. PMID: 29414793 Free PMC article.

7

Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.

Assimon VA, Southworth DR, Gestwicki JE. Assimon VA, et al. Biochemistry. 2015 Dec 8;54(48):7120-31. doi: 10.1021/acs.biochem.5b00801. Epub 2015 Nov 25. Biochemistry. 2015. PMID: 26565746 Free PMC article.

8

Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.

Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. Ravalin M, et al. Among authors: assimon va. Nat Chem Biol. 2019 Aug;15(8):786-794. doi: 10.1038/s41589-019-0322-6. Epub 2019 Jul 18. Nat Chem Biol. 2019. PMID: 31320752 Free PMC article.

9

The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.

Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. Connarn JN, et al. Among authors: assimon va. J Biol Chem. 2014 Jan 31;289(5):2908-17. doi: 10.1074/jbc.M113.519421. Epub 2013 Dec 10. J Biol Chem. 2014. PMID: 24327656 Free PMC article.

10

Hsp70 protein complexes as drug targets.

Assimon VA, Gillies AT, Rauch JN, Gestwicki JE. Assimon VA, et al. Curr Pharm Des. 2013;19(3):404-17. doi: 10.2174/138161213804143699. Curr Pharm Des. 2013. PMID: 22920901 Free PMC article. Review.

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