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Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA).
Tykvart J, Navrátil V, Kugler M, Šácha P, Schimer J, Hlaváčková A, Tenora L, Zemanová J, Dejmek M, Král V, Potáček M, Majer P, Jahn U, Brynda J, Řezáčová P, Konvalinka J. Tykvart J, et al. Among authors: dejmek m. SLAS Discov. 2020 Oct;25(9):1026-1037. doi: 10.1177/2472555220918836. Epub 2020 May 26. SLAS Discov. 2020. PMID: 32452709 Free article.
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Novotná B, Vaneková L, Zavřel M, Buděšínský M, Dejmek M, Smola M, Gutten O, Tehrani ZA, Pimková Polidarová M, Brázdová A, Liboska R, Štěpánek I, Vavřina Z, Jandušík T, Nencka R, Rulíšek L, Bouřa E, Brynda J, Páv O, Birkuš G. Novotná B, et al. Among authors: dejmek m. J Med Chem. 2019 Dec 12;62(23):10676-10690. doi: 10.1021/acs.jmedchem.9b01062. Epub 2019 Nov 27. J Med Chem. 2019. PMID: 31715099
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
Vavřina Z, Perlíková P, Milisavljević N, Chevrier F, Smola M, Smith J, Dejmek M, Havlíček V, Buděšínský M, Liboska R, Vaneková L, Brynda J, Boura E, Řezáčová P, Hocek M, Birkuš G. Vavřina Z, et al. Among authors: dejmek m. J Med Chem. 2022 Oct 27;65(20):14082-14103. doi: 10.1021/acs.jmedchem.2c01305. Epub 2022 Oct 6. J Med Chem. 2022. PMID: 36201304 Free PMC article.
Synthesis and anti-human immunodeficiency virus activity of substituted ( o,o-difluorophenyl)-linked-pyrimidines as potent non-nucleoside reverse transcriptase inhibitors.
Čechová L, Dejmek M, Baszczyňski O, Šaman D, Gao L, Hu E, Stepan G, Jansa P, Janeba Z, Šimon P. Čechová L, et al. Among authors: dejmek m. Antivir Chem Chemother. 2019 Jan-Dec;27:2040206619826265. doi: 10.1177/2040206619826265. Antivir Chem Chemother. 2019. PMID: 30788976 Free PMC article.
The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.
Klima M, Baumlova A, Chalupska D, Hřebabecký H, Dejmek M, Nencka R, Boura E. Klima M, et al. Among authors: dejmek m. Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1555-63. doi: 10.1107/S1399004715009505. Epub 2015 Jun 30. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26143926
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Mejdrová I, Chalupská D, Plačková P, Müller C, Šála M, Klíma M, Baumlová A, Hřebabecký H, Procházková E, Dejmek M, Strunin D, Weber J, Lee G, Matoušová M, Mertlíková-Kaiserová H, Ziebuhr J, Birkus G, Boura E, Nencka R. Mejdrová I, et al. Among authors: dejmek m. J Med Chem. 2017 Jan 12;60(1):100-118. doi: 10.1021/acs.jmedchem.6b01465. Epub 2016 Dec 22. J Med Chem. 2017. PMID: 28004945
Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors.
Štefek M, Chalupská D, Chalupský K, Zgarbová M, Dvořáková A, Krafčíková P, Li ASM, Šála M, Dejmek M, Otava T, Chaloupecká E, Kozák J, Kozic J, Vedadi M, Weber J, Mertlíková-Kaiserová H, Nencka R. Štefek M, et al. Among authors: dejmek m. ACS Omega. 2023 Jul 21;8(30):27410-27418. doi: 10.1021/acsomega.3c02815. eCollection 2023 Aug 1. ACS Omega. 2023. PMID: 37546609 Free PMC article.
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