Ishiguro N - Search Results

1

A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug-Drug-Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals.

Hanke N, Türk D, Selzer D, Ishiguro N, Ebner T, Wiebe S, Müller F, Stopfer P, Nock V, Lehr T. Hanke N, et al. Among authors: ishiguro n. Clin Pharmacokinet. 2020 Nov;59(11):1419-1431. doi: 10.1007/s40262-020-00896-w. Clin Pharmacokinet. 2020. PMID: 32449077 Free PMC article.

2

Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans.

Ishiguro N, Maeda K, Kishimoto W, Saito A, Harada A, Ebner T, Roth W, Igarashi T, Sugiyama Y. Ishiguro N, et al. Drug Metab Dispos. 2006 Jul;34(7):1109-15. doi: 10.1124/dmd.105.009175. Epub 2006 Apr 12. Drug Metab Dispos. 2006. PMID: 16611857

3

Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide.

Ishiguro N, Maeda K, Saito A, Kishimoto W, Matsushima S, Ebner T, Roth W, Igarashi T, Sugiyama Y. Ishiguro N, et al. Drug Metab Dispos. 2008 Apr;36(4):796-805. doi: 10.1124/dmd.107.018903. Epub 2008 Jan 7. Drug Metab Dispos. 2008. PMID: 18180273

4

The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers.

Yamada A, Maeda K, Ishiguro N, Tsuda Y, Igarashi T, Ebner T, Roth W, Ikushiro S, Sugiyama Y. Yamada A, et al. Among authors: ishiguro n. Pharmacogenet Genomics. 2011 Sep;21(9):523-30. doi: 10.1097/FPC.0b013e3283482502. Pharmacogenet Genomics. 2011. PMID: 21829131

5

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes.

Schaefer O, Ohtsuki S, Kawakami H, Inoue T, Liehner S, Saito A, Sakamoto A, Ishiguro N, Matsumaru T, Terasaki T, Ebner T. Schaefer O, et al. Among authors: ishiguro n. Drug Metab Dispos. 2012 Jan;40(1):93-103. doi: 10.1124/dmd.111.042275. Epub 2011 Oct 6. Drug Metab Dispos. 2012. PMID: 21979928

6

Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods.

Ishiguro N, Shimizu H, Kishimoto W, Ebner T, Schaefer O. Ishiguro N, et al. Drug Metab Dispos. 2013 Jan;41(1):149-58. doi: 10.1124/dmd.112.048470. Epub 2012 Oct 16. Drug Metab Dispos. 2013. PMID: 23073734

7

Impact of endogenous esterase activity on in vitro p-glycoprotein profiling of dabigatran etexilate in Caco-2 monolayers.

Ishiguro N, Kishimoto W, Volz A, Ludwig-Schwellinger E, Ebner T, Schaefer O. Ishiguro N, et al. Drug Metab Dispos. 2014 Feb;42(2):250-6. doi: 10.1124/dmd.113.053561. Epub 2013 Nov 8. Drug Metab Dispos. 2014. PMID: 24212377

8

In vitro predictability of drug-drug interaction likelihood of P-glycoprotein-mediated efflux of dabigatran etexilate based on [I]2/IC50 threshold.

Kishimoto W, Ishiguro N, Ludwig-Schwellinger E, Ebner T, Schaefer O. Kishimoto W, et al. Among authors: ishiguro n. Drug Metab Dispos. 2014 Feb;42(2):257-63. doi: 10.1124/dmd.113.053769. Epub 2013 Nov 8. Drug Metab Dispos. 2014. PMID: 24212378

9

The Use of Transporter Probe Drug Cocktails for the Assessment of Transporter-Based Drug-Drug Interactions in a Clinical Setting-Proposal of a Four Component Transporter Cocktail.

Ebner T, Ishiguro N, Taub ME. Ebner T, et al. Among authors: ishiguro n. J Pharm Sci. 2015 Sep;104(9):3220-8. doi: 10.1002/jps.24489. Epub 2015 May 15. J Pharm Sci. 2015. PMID: 25981193

10

Usefulness of A Model-Based Approach for Estimating In Vitro P-Glycoprotein Inhibition Potency in a Transcellular Transport Assay.

Kishimoto W, Ishiguro N, Ludwig-Schwellinger E, Ebner T, Maeda K, Sugiyama Y. Kishimoto W, et al. Among authors: ishiguro n. J Pharm Sci. 2016 Feb;105(2):891-896. doi: 10.1016/j.xphs.2015.11.006. J Pharm Sci. 2016. PMID: 26869433

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